[Meta analysis of the prevalence and risk factors of non-alcoholic fatty liver disease in overweight and obese children and adolescents in China].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-04-15 DOI:10.7499/j.issn.1008-8830.2408148

Yi Xiao, Yu-Fan Pan, Yu Dai, Yu-Jian Sun, Yue Zhou, Yu-Feng Yu

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引用次数: 0

Abstract

Objectives: To systematically evaluate the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in overweight and obese children and adolescents in China.

Methods: Databases including China National Knowledge Infrastructure, Wanfang Data, VIP Database, China Biomedical Literature Database, PubMed, Embase, Web of Science, and Cochrane Library were searched, from database inception to October 2024. Two researchers independently screened the literature, extracted data, and assessed the quality of the studies according to inclusion and exclusion criteria. A Meta analysis was conducted using Stata 16.0 software.

Results: A total of 42 studies involving 16 481 overweight and obese children and adolescents were included. The Meta analysis results showed that the prevalence of NAFLD among overweight and obese children in China was 43% (95%CI: 37%-48%). Factors associated with NAFLD included being male (OR=1.61, 95%CI: 1.17-2.04), increased weight (MD=10.33, 95%CI: 9.08-11.57), increased waist circumference (MD=5.49, 95%CI: 3.36-7.62), longer duration of obesity (MD=0.31, 95%CI: 0.02-0.61), higher body mass index (MD=3.11, 95%CI: 2.07-4.16), elevated fasting blood glucose levels (MD=0.17, 95%CI: 0.06-0.29), higher triglyceride levels (MD=0.32, 95%CI: 0.17-0.47), elevated total cholesterol levels (MD=0.15, 95%CI: 0.10-0.21), higher low-density lipoprotein cholesterol levels (MD=0.14, 95%CI: 0.04-0.23), increased alanine aminotransferase levels (MD=24.39, 95%CI: 18.57-30.20), increased aspartate aminotransferase levels (MD=12.49, 95%CI: 9.67-15.32), elevated serum insulin levels (MD=4.47, 95%CI: 2.57-6.36), higher homeostasis model assessment-insulin resistance (MD=0.45, 95%CI: 0.30-0.59), and elevated uric acid levels (MD=55.91, 95%CI: 35.49-76.32) (P<0.05).

Conclusions: The prevalence of NAFLD among overweight and obese children and adolescents in China is high. Male gender, increased weight, increased waist circumference, prolonged obesity duration, higher body mass index, dyslipidemia, and elevated levels of fasting blood glucose, liver enzymes, serum insulin, homeostasis model assessment-insulin resistance, and uric acid are potential risk factors for NAFLD in this population.

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[中国超重和肥胖儿童和青少年非酒精性脂肪肝患病率及危险因素的Meta分析]。

目的：系统评估中国超重和肥胖儿童和青少年非酒精性脂肪性肝病（NAFLD）的患病率和危险因素。方法：检索中国国家知识基础设施、万方数据、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science、Cochrane Library等数据库，检索时间为建库至2024年10月。两名研究人员独立筛选文献，提取数据，并根据纳入和排除标准评估研究的质量。采用Stata 16.0软件进行Meta分析。结果：共纳入42项研究，涉及16481名超重和肥胖儿童和青少年。Meta分析结果显示，中国超重和肥胖儿童中NAFLD的患病率为43% （95%CI: 37%-48%）。与NAFLD相关的因素包括男性（OR=1.61, 95%CI: 1.17-2.04）、体重增加（MD=10.33, 95%CI: 9.08-11.57）、腰围增加（MD=5.49, 95%CI: 3.36-7.62）、肥胖持续时间更长（MD=0.31, 95%CI: 0.02-0.61）、较高的体重指数（MD=3.11, 95%CI: 2.07-4.16）、空腹血糖水平升高（MD=0.17, 95%CI: 0.06-0.29）、较高的甘油三酯水平（MD=0.32, 95%CI: 0.17-0.47）、总胆固醇水平升高（MD=0.15, 95%CI: 0.47）。0.10 ~ 0.21)，低密度脂蛋白胆固醇水平升高（MD=0.14, 95%CI: 0.04 ~ 0.23），谷丙转氨酶水平升高（MD=24.39, 95%CI: 18.57 ~ 30.20），谷草转氨酶水平升高（MD=12.49, 95%CI: 9.67 ~ 15.32），血清胰岛素水平升高（MD=4.47, 95%CI: 2.57 ~ 6.36），稳态模型评估-胰岛素抵抗水平升高（MD=0.45, 95%CI: 0.30 ~ 0.59），尿酸水平升高（MD=55.91, 95%CI: 35.49 ~ 76.32） (p结论：在中国超重和肥胖的儿童和青少年中，NAFLD的患病率很高。男性、体重增加、腰围增加、肥胖持续时间延长、体重指数升高、血脂异常、空腹血糖、肝酶、血清胰岛素、体内平衡模型评估-胰岛素抵抗和尿酸水平升高是该人群NAFLD的潜在危险因素。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.