Iridoid glycosides from the leaves of Paederia foetida and their antinociceptive activities.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-15 DOI:10.1080/10286020.2025.2490108

Yu-Feng Chen, Wei Gong, Xue Sun

引用次数: 0

Abstract

A chemical investigation on the leaves of Paederia Foetida resulted into the isolation of two new iridoid glycosides, paefoetines A and B (1 and 2). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested in vivo for their antinociceptive properties. As a result, 1 exhibited potent antinociceptive activity and its ED₅₀ value (49.2 μmol/kg) was twofold less than those of the positive control drugs aspirin.

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黄连叶环烯醚萜苷类化合物及其抗伤活性研究。

从小檗叶中分离到两种新的环烯醚萜苷，paefoetines A和B（1和2）。所有化合物的结构通过1D和2D (1H-1H COSY， HMQC和HMBC) NMR光谱方法进行了分析。对分离得到的两种环烯醚萜苷进行了体内抗伤性实验。结果表明，1具有较强的抗伤感受活性，其ED50值（49.2 μmol/kg）比阳性对照药物阿司匹林低2倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.