Value of serum LncRNA KIF9-AS1 combined with CT signs in the diagnosis of benign and malignant early pulmonary nodules and its correlation with prognosis.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-05-09 DOI:10.1186/s13019-025-03438-2

Huichao Wu, Jian Liu, Zhongjun Jing, Zihua Qi, Xianjun Ma, Junying Zhao, Laichong Huang

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引用次数: 0

Abstract

Background: Early screening for lung cancer and early treatment of malignant pulmonary nodules (PNs) contribute a lot to reducing lung cancer mortality. Whether the highly expressed lncRNA KIF9-AS1 in multiple malignancies is associated with the development of malignant PNs is not clear. This study focused on the diagnosis and prognosis value of KIF9-AS1 in PNs patients.

Methods: The study population included 101 individuals with benign PNs and 172 patients diagnosed with malignant PNs. The expression of KIF9-AS1 was analyzed by qRT-PCR. The receiver operator characteristic (ROC) curve was plotted to evaluate the diagnostic performance while the Kaplan-Meier curve and multivariate Cox regression analysis were employed for prognosis. Correlation assessment was accomplished by Pearson correlation analysis.

Results: Differentiated expression of KIF9-AS1 was found in benign and malignant PNs groups. The expression of KIF9-AS1 was positively associated with carcinoembryonic antigen (CEA) and cytokeratin 19 fragments 21 - 1 (CYFRA21-1). KIF9-AS1 presented high accuracy in distinguishing malignant PNs from benign PNs, especially combined with computed tomography (CT). The expression level of KIF9-AS1, and nodule diameter were independent risk factors of poor prognosis.

Conclusions: Assessment of serum KIF9-AS1 level contributed to clinical diagnosis and prognosis of malignant PNs and also improved the diagnostic value of CT.

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血清LncRNA - KIF9-AS1结合CT征像对良、恶性早期肺结节的诊断价值及其与预后的关系

背景：早期筛查肺癌和早期治疗恶性肺结节（PNs）对降低肺癌死亡率有重要作用。多种恶性肿瘤中高表达的lncRNA KIF9-AS1是否与恶性PNs的发生相关尚不清楚。本研究主要探讨KIF9-AS1在PNs患者中的诊断及预后价值。方法：研究人群包括101例良性PNs和172例恶性PNs。采用qRT-PCR分析KIF9-AS1的表达情况。绘制受试者特征曲线（receiver operator characteristic， ROC）评价诊断效能，采用Kaplan-Meier曲线和多变量Cox回归分析评价预后。相关性评价采用Pearson相关分析。结果：KIF9-AS1在良性和恶性PNs组中表达有差异。KIF9-AS1的表达与癌胚抗原（CEA）和细胞角蛋白19片段21-1 （CYFRA21-1）呈正相关。KIF9-AS1在鉴别良性PNs和恶性PNs方面具有较高的准确性，特别是与CT相结合。KIF9-AS1表达水平、结节直径是预后不良的独立危险因素。结论：血清KIF9-AS1水平的评估有助于临床对恶性PNs的诊断和预后，提高了CT的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.