The Prenatal Diagnosis and Perinatal Management of Congenital Long QT Syndrome: A Comprehensive Literature Review and Recent Updates.

IF 2.4 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Stefani Samples, Sara Cherny, Nitin Madan, Jeff Hong, Sheena A Mansukhani, Janette F Strasburger, Michael R Carr, Sheetal R Patel
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引用次数: 0

Abstract

Congenital long QT syndrome (LQTS) is a group of heritable conditions that are associated with cardiac repolarization abnormalities characterized by QT prolongation on electrocardiogram and the risk of life-threatening arrhythmias. The prenatal detection of LQTS presents significant challenges for clinicians, and a multidisciplinary approach is required for optimal prenatal and postnatal management. In this comprehensive literature review, we describe strategies for the fetal diagnosis of LQTS with variable initial presentation, genetic testing in suspected fetal LQTS, the utility of fetal magnetocardiography as an additional diagnostic tool, prenatal management, and postnatal treatment. We focus on a multidisciplinary team approach including fetal cardiology, adult and pediatric electrophysiology, neonatology, maternal-fetal medicine, and genetic counselors, all playing vital roles in the comprehensive prenatal management and orchestration of postnatal treatment to optimize neonatal outcomes.

先天性长QT综合征的产前诊断和围产期处理:综合文献综述和最新进展。
先天性长QT综合征(LQTS)是一组与心脏复极异常相关的遗传性疾病,其特征为心电图QT间期延长和危及生命的心律失常风险。LQTS的产前检测对临床医生提出了重大挑战,需要多学科的方法来优化产前和产后管理。在这篇全面的文献综述中,我们描述了具有可变初始表现的LQTS的胎儿诊断策略,可疑胎儿LQTS的基因检测,胎儿心磁图作为附加诊断工具的应用,产前管理和产后治疗。我们专注于多学科团队的方法,包括胎儿心脏病学,成人和儿童电生理学,新生儿科,母胎医学和遗传咨询师,所有在全面的产前管理和产后治疗的编排中发挥重要作用,以优化新生儿结局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
12.50%
发文量
381
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