Nanoengineered Shape-Memory Hemostat.

IF 8.3 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Small Science Pub Date : 2024-12-11 eCollection Date: 2025-02-01 DOI:10.1002/smsc.202400321
Sarah E Hargett, Giriraj K Lokhande, Joseph Duran, Zanir Hirani, Lindy K Jang, Samantha Foster, Kaivalya A Deo, Sasha George, Mahjabeen Javed, Taylor H Ware, Duncan J Maitland, Akhilesh K Gaharwar
{"title":"Nanoengineered Shape-Memory Hemostat.","authors":"Sarah E Hargett, Giriraj K Lokhande, Joseph Duran, Zanir Hirani, Lindy K Jang, Samantha Foster, Kaivalya A Deo, Sasha George, Mahjabeen Javed, Taylor H Ware, Duncan J Maitland, Akhilesh K Gaharwar","doi":"10.1002/smsc.202400321","DOIUrl":null,"url":null,"abstract":"<p><p>Uncontrolled hemorrhage is the predominant cause of preventable combat deaths. Various biomaterials serve as hemostatic agents due to their procoagulant or absorptive activity. However, these biomaterials often lack expansion capabilities, which severely limits use in noncompressible wounds. This study combines a hemostatic nanocomposite with a shape-memory polymer foam to design a composite material with both hemostatic and physical expansion properties. This composite is fabricated in two formulations: a foam externally coated in a highly concentrated nanocomposite (\"coated composite\") and a foam containing a diluted nanocomposite infused throughout its pores (\"infused composite\"). Both formulations retain the shape-memory foam's expansion property. Further, the coated composite shows improved fluid uptake (>2-fold) versus infused composites or foam. The nanocomposite component dissociates from the foam under degradative conditions, with the foam remaining stable for 30 days. Hemostatic studies illustrate that the coated composite reduces the clotting time by ≈20%. Alternatively, the infused composite improves clotting over a larger distance (up to ≈2× distance from the composite). These results signify a modular hemostatic ability: the coated composite reduces clotting and improves fluid uptake, while the infused composite achieves diffuse clotting and maintains mechanical properties. Thus, these materials pose a strong potential for use in noncompressible wounds.</p>","PeriodicalId":29791,"journal":{"name":"Small Science","volume":"5 2","pages":"2400321"},"PeriodicalIF":8.3000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934902/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smsc.202400321","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

Uncontrolled hemorrhage is the predominant cause of preventable combat deaths. Various biomaterials serve as hemostatic agents due to their procoagulant or absorptive activity. However, these biomaterials often lack expansion capabilities, which severely limits use in noncompressible wounds. This study combines a hemostatic nanocomposite with a shape-memory polymer foam to design a composite material with both hemostatic and physical expansion properties. This composite is fabricated in two formulations: a foam externally coated in a highly concentrated nanocomposite ("coated composite") and a foam containing a diluted nanocomposite infused throughout its pores ("infused composite"). Both formulations retain the shape-memory foam's expansion property. Further, the coated composite shows improved fluid uptake (>2-fold) versus infused composites or foam. The nanocomposite component dissociates from the foam under degradative conditions, with the foam remaining stable for 30 days. Hemostatic studies illustrate that the coated composite reduces the clotting time by ≈20%. Alternatively, the infused composite improves clotting over a larger distance (up to ≈2× distance from the composite). These results signify a modular hemostatic ability: the coated composite reduces clotting and improves fluid uptake, while the infused composite achieves diffuse clotting and maintains mechanical properties. Thus, these materials pose a strong potential for use in noncompressible wounds.

纳米工程形状记忆止血器。
不受控制的出血是可预防的战斗死亡的主要原因。各种生物材料由于其促凝或吸收活性而用作止血剂。然而,这些生物材料通常缺乏扩展能力,这严重限制了在不可压缩伤口中的应用。本研究将止血纳米复合材料与形状记忆聚合物泡沫相结合,设计了一种兼具止血和物理膨胀性能的复合材料。这种复合材料以两种配方制成:一种是外部包覆有高浓度纳米复合材料的泡沫(“包覆复合材料”),另一种是含有稀释纳米复合材料的泡沫(“包覆复合材料”)。两种配方都保留了形状记忆泡沫的膨胀特性。此外,与注入复合材料或泡沫相比,涂层复合材料的流体吸收率提高了2倍。纳米复合材料组分在降解条件下与泡沫分离,泡沫保持稳定30天。止血研究表明,包覆复合材料可减少约20%的凝血时间。或者,注入的复合材料在更大的距离上改善凝血(到复合材料的距离≈2倍)。这些结果表明了模块化的止血能力:涂层复合材料减少凝血并改善液体摄取,而注入的复合材料实现弥漫性凝血并保持机械性能。因此,这些材料在不可压缩伤口中具有很大的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
14.00
自引率
2.40%
发文量
0
期刊介绍: Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信