Hydrostatic low-volume enemas in infants with birth weight ≤1000 g or gestational age ≤28 weeks: A controlled interventional study.

IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Tabea Stock, Anne-Marie Kamp, Markus Waitz, Teresa Riedl-Seifert, Andreas C Jenke
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引用次数: 0

Abstract

Objective: This study evaluated the safety and efficacy of standardized minimally invasive hydrostatic low-volume saline enemas in infants with a birth weight ≤1000 g or gestational age ≤28 weeks and delayed meconium passage.

Methods: Conducted at the Neonatology Department of Klinikum Kassel, Germany, this monocentric controlled interventional study included a historic control group and a prospective intervention group. Infants born between January 2019 and October 2022 were included. The control group received manual enemas using varied techniques, while the intervention group underwent standardized hydrostatic low-volume saline enemas at predefined intervals. Key outcomes assessed included gastrointestinal complications (necrotizing enterocolitis [NEC], focal intestinal perforation [FIP], and meconium plug syndrome [MPS]), morbidity, mortality, stool and feeding parameters, and staff evaluations.

Results: A total of 42 infants were included in the control group and 74 in the intervention group. NEC incidence was lower in the intervention group (4.1%) compared to the control group (9.5%), as was the rate of FIP (2.7% vs. 7.1%). Morbidity showed a decreasing trend in the intervention group (6.8% vs. 16.7%), and the combined morbidity and mortality rate was significantly lower (6.8% vs. 19.1%). Despite reduced stool frequency, enteral feeding tolerance improved in the intervention group.

Conclusion: An unstandardized approach to rectal interventions may increase the need for surgical interventions, whereas standardized hydrostatic low-volume saline enemas are a safe and effective alternative to conventional rectal interventions, offering improved comfort and potentially reducing intestinal morbidity in infants with a birth weight ≤1000 g or gestational age ≤28 weeks.

Trial identification number: DRKS00024191 (https://drks.de/search/de/trial/DRKS00024191).

出生体重≤1000g或胎龄≤28周婴儿的静水小容量灌肠:一项对照介入研究
目的:本研究评价标准化微创静水小容量生理盐水灌肠治疗出生体重≤1000g或胎龄≤28周且胎便通过延迟的婴儿的安全性和有效性。方法:在德国Klinikum Kassel新生儿科进行的单中心对照干预研究包括历史对照组和前瞻性干预组。2019年1月至2022年10月出生的婴儿也包括在内。对照组接受不同技术的人工灌肠,而干预组在预定的时间间隔内接受标准化的静水小容量盐水灌肠。评估的主要结局包括胃肠道并发症(坏死性小肠结肠炎[NEC]、局灶性肠穿孔[FIP]和胎便塞综合征[MPS])、发病率、死亡率、粪便和喂养参数以及工作人员评价。结果:对照组42例,干预组74例。干预组NEC发生率(4.1%)低于对照组(9.5%),FIP发生率(2.7%)低于对照组(7.1%)。干预组发病率呈下降趋势(6.8%比16.7%),综合发病率和死亡率显著降低(6.8%比19.1%)。尽管大便次数减少,干预组的肠内喂养耐受性得到改善。结论:未标准化的直肠干预方法可能会增加手术干预的需求,而标准化的静水小容量生理盐水灌肠是传统直肠干预的一种安全有效的替代方法,可以提高婴儿的舒适度,并有可能降低出生体重≤1000 g或胎龄≤28周的婴儿的肠道发病率。试验识别号:DRKS00024191 (https://drks.de/search/de/trial/DRKS00024191)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.30
自引率
13.80%
发文量
467
审稿时长
3-6 weeks
期刊介绍: ​The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.
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