{"title":"Unusual Clinical Course in a Case with Relapsing Polychondritis Showing Hypertrophic Pachymeningitis Complicated by a Klebsiella pneumoniae Infection.","authors":"Ken Yasuda, Takakuni Maki, Kohei Nishimura, Hajime Yoshifuji, Masakazu Okawa, Akio Ikeda, Riki Matsumoto, Ryosuke Takahashi","doi":"10.2169/internalmedicine.5334-25","DOIUrl":null,"url":null,"abstract":"<p><p>Relapsing polychondritis (RP) is a rare autoimmune disease that may involve the central nervous system. We herein present the first reported case of hypertrophic pachymeningitis (HP) in an RP patient with a concurrent Klebsiella pneumoniae infection. A 48-year-old man developed transient left-sided weakness and numbness, and brain MRI showed diffuse pachymeningitis. Cultures from a dural biopsy identified K. pneumoniae, and RP was diagnosed using an auricular cartilage biopsy. Treatment with corticosteroids and infliximab resulted in symptom resolution. This case highlights the importance of considering bacterial infections in HP associated with RP, while also providing insight into its pathophysiology.</p>","PeriodicalId":13719,"journal":{"name":"Internal Medicine","volume":" ","pages":"3146-3149"},"PeriodicalIF":1.0000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12659956/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2169/internalmedicine.5334-25","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Relapsing polychondritis (RP) is a rare autoimmune disease that may involve the central nervous system. We herein present the first reported case of hypertrophic pachymeningitis (HP) in an RP patient with a concurrent Klebsiella pneumoniae infection. A 48-year-old man developed transient left-sided weakness and numbness, and brain MRI showed diffuse pachymeningitis. Cultures from a dural biopsy identified K. pneumoniae, and RP was diagnosed using an auricular cartilage biopsy. Treatment with corticosteroids and infliximab resulted in symptom resolution. This case highlights the importance of considering bacterial infections in HP associated with RP, while also providing insight into its pathophysiology.
期刊介绍：
Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine.
Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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