Advances and trends for astaxanthin synthesis in Phaffia rhodozyma.

IF 4.3 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Microbial Cell Factories Pub Date : 2025-05-06 DOI:10.1186/s12934-025-02704-1

Jiajun Sun, Zhaokun Zhang, Le Gao, Fan Yang

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Abstract

Astaxanthin, a carotenoid endowed with potent antioxidant capacity, exhibits considerable application prospects in nutraceuticals, pharmaceuticals, and cosmetics. In contrast to the chemical synthesis method, the biosynthesis of astaxanthin is undoubtedly a greener and more environmentally friendly production approach. In this review, we comprehensively review the biosynthetic pathways and multiple strategies for astaxanthin synthesis in Phaffia rhodozyma. Some biotechnology advancements for increasing the yield of astaxanthin in Phaffia rhodozyma encompass mutagenesis breeding, genetic modification, and optimizing fermentation conditions, thereby opening up new avenues for its application in functional foods and feed. Nevertheless, the yield of product synthesis is constrained by the host metabolic stoichiometry. Besides breaking the threshold of astaxanthin production and alleviating the impact of astaxanthin accumulation on cell growth, a comprehensive comprehension of multiple interconnected metabolic pathways and complex regulatory mechanisms is indispensable for significantly enhancing astaxanthin production. This review presents some prospects of integrating digital concepts into astaxanthin production to aid in overcoming current challenges.

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法菲酵母虾青素合成研究进展及趋势。

虾青素是一类具有较强抗氧化能力的类胡萝卜素，在保健品、医药、化妆品等领域具有广阔的应用前景。与化学合成法相比，生物合成虾青素无疑是一种更加绿色环保的生产方法。本文综述了法菲菌红酵母合成虾青素的生物合成途径和多种策略。法菲酵母在提高虾青素产量方面的一些生物技术进展包括诱变育种、基因改造和优化发酵条件，从而为其在功能食品和饲料中的应用开辟了新的途径。然而，产物合成的产率受到宿主代谢化学计量学的限制。除了突破虾青素产生的门槛，减轻虾青素积累对细胞生长的影响外，全面了解多种相互关联的代谢途径和复杂的调控机制是显著提高虾青素产生的必要条件。本文综述了将数字概念整合到虾青素生产中的一些前景，以帮助克服当前的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial Cell Factories 工程技术-生物工程与应用微生物

CiteScore

9.30

自引率

4.70%

发文量

235

审稿时长

2.3 months

期刊介绍： Microbial Cell Factories is an open access peer-reviewed journal that covers any topic related to the development, use and investigation of microbial cells as producers of recombinant proteins and natural products, or as catalyzers of biological transformations of industrial interest. Microbial Cell Factories is the world leading, primary research journal fully focusing on Applied Microbiology. The journal is divided into the following editorial sections: -Metabolic engineering -Synthetic biology -Whole-cell biocatalysis -Microbial regulations -Recombinant protein production/bioprocessing -Production of natural compounds -Systems biology of cell factories -Microbial production processes -Cell-free systems