Sodium butyrate aids brain injury repair in neonatal rats.

IF 1.7 4区生物学 Q3 BIOLOGY

Open Life Sciences Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.1515/biol-2022-1046

Jing Zhao, Jun Zhang, Can Yang, Linlin Yin, Li Hou, Lin Jiang

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Abstract

The aim of this study is to investigate the effects and mechanism of action of sodium butyrate (SB) on brain injury repair in neonatal rats. 126 neonatal SD rats were randomly allocated to 7 groups, and necrotizing enterocolitis (NEC) and hypoxic-ischemic brain injury (HIBI) rat models were established. Hematoxylin and eosin staining showed that SB intervention alleviated intestinal and brain injuries in the HIBI + SB, NEC + SB, and NEC + HIBI + SB groups. Compared to the NEC and NEC + HIBI groups, the NEC + SB and NEC + HIBI + SB groups had significantly higher interleukin (IL)-10 and lower IL-17 levels (P < 0.05). Immunohistochemistry revealed increased Bcl-2 expression and decreased Bax expression in the NEC + SB and NEC + HIBI + SB groups compared to the NEC and NEC + HIBI groups in intestinal and brain tissues (P < 0.05). Compared to the control group (CG), gut microbiota diversity decreased in the HIBI, NEC, and NEC + HIBI groups, and increased significantly in the HIBI + SB, NEC + SB, and NEC + HIBI + SB groups. SB may alleviate brain injury by modulating gut microbiota, affecting IL-10 and IL-17 levels, and regulating Bcl-2 and Bax expression in intestinal and brain tissues.

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丁酸钠对新生大鼠脑损伤的修复作用。

本研究旨在探讨丁酸钠（SB）对新生大鼠脑损伤修复的作用及其机制。126只新生SD大鼠随机分为7组，分别建立坏死性小肠结肠炎（NEC）和缺氧缺血性脑损伤（HIBI）大鼠模型。苏木精和伊红染色显示，SB干预减轻了HIBI + SB组、NEC + SB组和NEC + HIBI + SB组的肠道和脑损伤。与NEC和NEC + HIBI组相比，NEC + SB组和NEC + HIBI + SB组白细胞介素(IL)-10水平显著升高，IL-17水平显著降低（P < 0.05）。免疫组化结果显示，与NEC和NEC + HIBI组相比，NEC + SB组和NEC + HIBI + SB组小肠和脑组织Bcl-2表达升高，Bax表达降低（P < 0.05）。与对照组（CG）相比，HIBI、NEC和NEC + HIBI组肠道菌群多样性降低，HIBI + SB、NEC + SB和NEC + HIBI + SB组肠道菌群多样性显著增加。SB可能通过调节肠道菌群，影响IL-10和IL-17水平，调节肠脑组织Bcl-2和Bax表达来减轻脑损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Life Sciences BIOLOGY-

CiteScore

2.50

自引率

4.50%

发文量

131

审稿时长

43 weeks

期刊介绍： Open Life Sciences (previously Central European Journal of Biology) is a fast growing peer-reviewed journal, devoted to scholarly research in all areas of life sciences, such as molecular biology, plant science, biotechnology, cell biology, biochemistry, biophysics, microbiology and virology, ecology, differentiation and development, genetics and many others. Open Life Sciences assures top quality of published data through critical peer review and editorial involvement throughout the whole publication process. Thanks to the Open Access model of publishing, it also offers unrestricted access to published articles for all users.