Infectivity and persistence of bovine leukemia virus in human breast cells: assessing a possible zoonotic link to cancer.

IF 1.8 3区农林科学 Q2 VETERINARY SCIENCES

Veterinary Research Communications Pub Date : 2025-04-22 DOI:10.1007/s11259-025-10738-4

Pedro Edgardo Moran, María Victoria Nieto Farías, Guillermina Laura Dolcini, María Carolina Ceriani

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引用次数: 0

Abstract

The study analyzes the potential link between bovine leukemia virus (BLV), an oncogenic retrovirus in cattle, and human breast cancer. BLV infects lymphocytes in cattle, causing persistent infections; while most animals are asymptomatic, some develop lymphosarcoma. The detection of BLV proviral DNA in milk and meat, along with antibodies and proviral DNA in humans, suggests possible zoonotic transmission. In controlled conditions, human mammary epithelial cells (MCF-10 A) were infected with BLV, and the effect of 17-β estradiol (E2) was assessed as a model for natural exposure. BLV integrated its DNA into human cells, increasing the proviral load in the presence of E2, suggesting E2 enhances viral integration. The virus replicated and produced infectious particles capable of infecting bovine mammary cells (MAC-T). Findings suggest BLV could establish infections in human mammary cells under certain conditions, potentially contributing to cancer development. The study highlights the need for further research into its zoonotic potential and emphasizes the importance of food safety practices, particularly regarding raw milk consumption.

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牛白血病病毒在人乳腺细胞中的传染性和持久性：评估与癌症的可能人畜共患联系。

该研究分析了牛白血病病毒（BLV）（牛的一种致癌逆转录病毒）与人类乳腺癌之间的潜在联系。BLV感染牛的淋巴细胞，引起持续性感染；虽然大多数动物无症状，但有些动物会发展成淋巴肉瘤。在牛奶和肉类中检测到BLV原病毒DNA，以及在人体内检测到抗体和原病毒DNA，表明可能存在人畜共患传播。在控制条件下，人乳腺上皮细胞（mcf - 10a）感染BLV，并评估17-β雌二醇（E2）作为自然暴露模型的影响。BLV将其DNA整合到人类细胞中，在E2存在的情况下增加了前病毒载量，表明E2增强了病毒整合。病毒复制并产生能够感染牛乳腺细胞（MAC-T）的感染性颗粒。研究结果表明，在某些条件下，BLV可以在人类乳腺细胞中建立感染，可能导致癌症的发展。该研究强调需要进一步研究其人畜共患的可能性，并强调食品安全措施的重要性，特别是在原料奶消费方面。

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来源期刊

Veterinary Research Communications 农林科学-兽医学

CiteScore

2.50

自引率

0.00%

发文量

173

审稿时长

3 months

期刊介绍： Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.