Age dependency of neurometabolite T1 relaxation times

IF 3 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance in Medicine Pub Date : 2025-04-14 DOI:10.1002/mrm.30507

Saipavitra Murali-Manohar, Helge J. Zöllner, Kathleen E. Hupfeld, Yulu Song, Emily E. Carter, Vivek Yedavalli, Steve C. N. Hui, Dunja Simicic, Aaron T. Gudmundson, Gizeaddis Lamesgin Simegn, Christopher W. Davies-Jenkins, Georg Oeltzschner, Eric C. Porges, Richard A. E. Edden

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引用次数: 0

Abstract

Purpose

To measure T₁ relaxation times of metabolites at 3 T in a healthy aging population and investigate age dependence.

Methods

A cohort of 101 healthy adults was recruited with approximately 10 male and 10 female participants in each “decade” band: 18 to 29, 30 to 39, 40 to 49, 50 to 59, and 60+ years old. Inversion-recovery PRESS data (TE/TR: 30/2000 ms) were acquired at 8 inversion times (TIs) (300, 400, 511, 637, 780, 947, 1148, and 1400 ms) from voxels in white-matter-rich centrum semiovale (CSO) and gray-matter-rich posterior cingulate cortex (PCC). Modeling of TI-series spectra was performed in Osprey 2.5.0. Quantified metabolite amplitudes for total N-acetylaspartate (tNAA_2.0), total creatine at 3.0 ppm (tCr_3.0), and 3.9 ppm (tCr_3.9), total choline (tCho), myo-inositol (mI), and the sum of glutamine and glutamate (Glx) were modeled to calculate T₁ relaxation times of metabolites.

Results

T₁ relaxation times of tNAA_2.0 in CSO and tNAA_2.0, tCr_3.0, mI, and Glx in PCC decreased with age. These correlations remained significant when controlling for cortical atrophy. T₁ relaxation times were significantly different between PCC and CSO for all metabolites except tCr_3.0. We also propose linear models for predicting metabolite T₁s at 3 T to be used in future aging studies.

Conclusion

Metabolite T₁ relaxation times change significantly with age, an effect that will be important to consider for accurate quantitative MRS, particularly in studies of aging.

查看原文本刊更多论文

神经代谢物T1放松时间的年龄依赖性。

目的：测定健康老年人群3t时代谢物T1松弛时间，探讨年龄依赖性。方法：招募了101名健康成年人，每个“十年”组约有10名男性和10名女性参与者：18至29岁，30至39岁，40至49岁，50至59岁和60岁以上。在8次反演（TIs）（300、400、511、637、780、947、1148和1400 ms）中，从富含白质的半叶中央（CSO）和富含灰质的后扣带皮层（PCC）的体素中获得反演-恢复PRESS数据（TE/TR: 30/2000 ms）。在Osprey 2.5.0中对ti系列光谱进行建模。通过对总n -乙酰天冬氨酸（tNAA2.0）、3.0 ppm （tCr3.0）和3.9 ppm （tCr3.9）、总胆碱（tCho）、肌醇（mI）和谷氨酰胺和谷氨酸（Glx）的量化代谢产物振幅进行建模，计算代谢产物的T1松弛时间。结果：CSO中tNAA2.0 T1弛豫时间随年龄增加而减少，PCC中tNAA2.0、tCr3.0、mI、Glx随年龄增加而减少。当控制皮质萎缩时，这些相关性仍然显著。除tCr3.0外，PCC和CSO对所有代谢物的T1松弛时间均有显著差异。我们还提出了预测3t时代谢物T1s的线性模型，用于未来的衰老研究。结论：代谢物T1弛豫时间随着年龄的增长而显著变化，这一效应对于精确定量MRS，特别是在衰老研究中，将是重要的考虑因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance in Medicine 医学-核医学

CiteScore

6.70

自引率

24.20%

发文量

376

审稿时长

2-4 weeks

期刊介绍： Magnetic Resonance in Medicine (Magn Reson Med) is an international journal devoted to the publication of original investigations concerned with all aspects of the development and use of nuclear magnetic resonance and electron paramagnetic resonance techniques for medical applications. Reports of original investigations in the areas of mathematics, computing, engineering, physics, biophysics, chemistry, biochemistry, and physiology directly relevant to magnetic resonance will be accepted, as well as methodology-oriented clinical studies.