Comparative Study of Sonazoid and SonoVue Contrast-Enhanced Ultrasound Quantitative Analysis Parameters in Peripheral Lung Cancer Lesions.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-04-15 DOI:10.1002/jcu.24011

Guosheng Liang, Wuxi Chen, Jiaxin Tang, Tingting Jiang, Yuxin Zhang, Shiyu Zhang, Qing Tang, Liantu He

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引用次数: 0

Abstract

Purpose: Lung cancer is a leading cause of death; however, its diagnosis needs to be improved. This study aimed to compare the performances of the contrast agents Sonazoid and SonoVue in quantitative analysis in the contrast-enhanced ultrasound (CEUS) of peripheral lung cancer lesions (PLCLs).

Methods: This retrospective study included patients with PLCLs between January 2021 and January 2024. They were divided into the Sonazoid-CEUS (50 patients) and SonoVue-CEUS (53 patients) groups. In the CEUS video, lesions and adjacent normal lung tissues were selected as regions of interest to obtain time-intensity curves. Seven CEUS indicators were used to compare the performances of the two contrast agents.

Results: The arrival times (ATs) were 13.1 ± 5.2 s and 11.5 ± 3.7 s for PLCLs (p = 0.087), respectively, and 8.0 ± 4.1 s and 7.0 ± 4.2 s for adjacent lung tissues (p = 0.197), respectively, in the Sonazoid and SonoVue groups. The peak intensity (PI) and area under the curve (AUC) of the lesions in the Sonazoid group were significantly lower than those in the SonoVue group (PI: 25.0 ± 11.5 vs. 35.8 ± 7.9, p < 0.001; AUC: 2365.2 ± 1708.2 vs. 4309.5 ± 1252.1, p < 0.001). The time to peak (TTP), mean transition time (MTT), and lesion-lung PI difference (ΔPI) in the Sonazoid group were significantly higher than those in the SonoVue group (TTP: 36.3 ± 13.8 s vs. 24.4 ± 8.7 s, p < 0.001; MTT: 119.6 ± 45.3 s vs. 80.6 ± 21.4 s, p < 0.001; ΔPI: 14.3 ± 10.9 vs. 8.4 ± 6.1, p < 0.01).

Conclusion: Sonazoid and SonoVue exhibited comparable quantitative performances in CEUS of PLCLs; the higher ΔPI of Sonazoid suggests it may enhance the contrast between lesions and adjacent tissues. The study's findings could help improve lung cancer diagnosis.

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索那唑与索诺维超声造影定量分析参数在周围性肺癌病变中的比较研究。

目的：肺癌是导致死亡的主要原因；然而，其诊断还有待改进。本研究旨在比较对比剂Sonazoid和SonoVue在外周肺癌病变（PLCLs）超声造影（CEUS）定量分析中的性能。方法：本回顾性研究纳入了2021年1月至2024年1月期间的plcl患者。将患者分为sonazoids - ceus组（50例）和SonoVue-CEUS组（53例）。在超声造影视频中，病变和邻近的正常肺组织被选择为感兴趣的区域，以获得时间-强度曲线。采用7项超声造影指标比较两种造影剂的性能。结果：Sonazoid组和SonoVue组plcl的到达时间分别为13.1±5.2 s和11.5±3.7 s (p = 0.087)，相邻肺组织的到达时间分别为8.0±4.1 s和7.0±4.2 s （p = 0.197）。Sonazoid组病变的峰值强度（PI）和曲线下面积（AUC）明显低于SonoVue组（PI: 25.0±11.5 vs. 35.8±7.9,p）。结论：Sonazoid和SonoVue在PLCLs超声造影中的定量表现相当；较高的ΔPI表明索那唑可以增强病变与邻近组织的对比。这项研究的发现可能有助于提高肺癌的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.