Contrast Enhanced Ultrasound: A Quantitative Ultrasound Imaging Mode for the Differential Diagnosis of Benign and Malignant Thyroid Nodules.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-04-29 DOI:10.1002/jcu.24030

Jia Zhan, Fang Li, Ji Ma, Xin Li, Long Liu, Rong Wu

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引用次数: 0

Abstract

Objective: To compare the qualitative contrast enhanced ultrasound (CEUS) performance with grayscale US with the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) in differentiating benign and malignant thyroid nodules.

Methods: In this retrospective study, 539 patients with thyroid nodules underwent grayscale US and CEUS. Four predictive models including grayscale US and CEUS sonographic features were constructed using univariable and multivariable logistic regression.

Results: A total of 539 thyroid nodules with confirmed cytological results (350 malignant thyroid nodules) in 539 participants were involved. Four predictive models incorporated nodule features at ACR TI-RADS, CEUS features (enhancement degree, homogeneity and rim enhancement), quantitative CEUS features (peak intensity) and ACR TI-RADS with quantitative PI. In fine-needle aspiration biopsy or pathologic results in thyroid nodules, the highest area under the receiver operating characteristic curve (AUC) was 0.87 (95% CI: 0.84, 0.90) for the ACR TI-RADS with quantitative PI model, which had a significant difference compared to the other three models (p < 0 0.05).

Conclusion: TI-RADS with quantitative PI model played a better diagnostic performance in differentiating benign and malignant thyroid nodules.

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超声造影增强：定量超声成像模式鉴别诊断良恶性甲状腺结节。

目的：比较灰阶超声定性增强超声（CEUS）与美国放射学会甲状腺影像报告与数据系统（ACR TI-RADS）鉴别甲状腺良恶性结节的表现。方法：回顾性研究539例甲状腺结节患者行灰度超声和超声造影。采用单变量和多变量logistic回归方法构建了灰度超声和超声超声特征预测模型。结果：539名参与者共539个甲状腺结节，细胞学结果证实（其中恶性甲状腺结节350个）。四种预测模型包括ACR TI-RADS的结节特征、CEUS特征（增强程度、均匀性和边缘增强）、定量CEUS特征（峰值强度）和ACR TI-RADS与定量PI。在细针穿刺活检或甲状腺结节病理结果中，定量PI模型的ACR TI-RADS的受者工作特征曲线下面积（AUC）最高为0.87 (95% CI: 0.84, 0.90)，与其他三种模型相比差异有统计学意义(p)。结论：定量PI模型的TI-RADS在甲状腺结节良恶性鉴别中具有更好的诊断性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.