Selective Toxicity Mechanisms of Carbon Nanotubes and Near-Infrared Light Wave on the Colon and Hepatoma Cancer Cells.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Iranian Journal of Pharmaceutical Research Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI:10.5812/ijpr-157296

Farshad Lotfollahzadeh, Nasim Nobari, Fatemeh Ghanbary, Hossein Hooshyar

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引用次数: 0

Abstract

Background: Cancer is a devastating disease with varying mortality rates and severe treatment side effects. Researchers are exploring alternative treatments that target cancer cells with high selectivity and minimal side effects. Photothermal therapy has shown promise as one such treatment option.

Objectives: Single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) can penetrate cellular membranes and convert near-infrared light into heat for photothermal therapy (PTT).

Methods: In a recent study, carbon nanotubes (CNTs) were used in combination with PTT to treat HT29 and PCL/PRF/5 cancerous cells for different durations (6, 12, 24, 48, and 72 hours). The cytotoxicity of each treatment was evaluated through MTT assay, reactive oxygen species (ROS) analysis, lipid peroxidation, lysosomal membrane integrity, and protein carbonyl analysis.

Results: The study found that SWCNTs, MWCNTs, and PTT each individually had a significant cytotoxic effect on cancer cells. However, when used together, they were even more effective in destroying cancer cells. Combining SWCNTs with PTT resulted in the highest level of cytotoxicity.

Conclusions: These findings suggest that using CNTs, especially SWCNTs, in combination with PTT shows promise for treating cancer.

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碳纳米管和近红外光波对结肠癌和肝癌细胞的选择性毒性机制。

背景：癌症是一种具有不同死亡率和严重治疗副作用的毁灭性疾病。研究人员正在探索针对癌细胞的高选择性和最小副作用的替代疗法。光热疗法作为一种这样的治疗选择已经显示出了希望。目的：单壁碳纳米管（SWCNTs）和多壁碳纳米管（MWCNTs）可以穿透细胞膜，将近红外光转化为热，用于光热治疗（PTT）。方法：在最近的一项研究中，使用碳纳米管（CNTs）联合PTT治疗HT29和PCL/PRF/5癌细胞，治疗时间不同（6、12、24、48和72小时）。通过MTT分析、活性氧（ROS）分析、脂质过氧化、溶酶体膜完整性和蛋白质羰基分析来评估每种处理的细胞毒性。结果：研究发现SWCNTs、MWCNTs和PTT各自对癌细胞具有显著的细胞毒性作用。然而，当它们一起使用时，它们在摧毁癌细胞方面甚至更有效。SWCNTs与PTT联合使用导致最高水平的细胞毒性。结论：这些发现表明，使用CNTs，特别是SWCNTs与PTT联合治疗癌症有希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Pharmaceutical Research 医学-药学

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

2 months

期刊介绍： The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.