A prospective study describing splanchnic NIRS and clinical outcomes in encephalopathic neonates receiving minimal enteral nutrition during therapeutic hypothermia.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-04-10 DOI:10.1038/s41372-025-02270-9

Tatiana A Nuzum, Sean M Bailey, Martha Caprio, Elena V Wachtel

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引用次数: 0

Abstract

Objective: To compare regional splanchnic oxygenation (SrSO2) levels and clinical outcomes between infants who received minimal enteral nutrition (MEN) during Therapeutic Hypothermia (TH), and those who did not.

Study design: A prospective, interventional cohort study with a historic control group at two Regional Perinatal Centers (NCT05471336).

Results: Participant demographics and clinical illness severity were similar between MEN (n = 40) and control (n = 40) groups. There were no significant safety events. SrSO2 levels were normal in both groups throughout. Subjects that received MEN experienced fewer central line days (5.8 v 6.9, p = 0.005) and higher rates of human milk feeding (77% v 46%, p = 0.010), and achieved full oral feeds sooner (9.9 v 13.4 days, p = 0.043).

Conclusion: Splanchnic tissue oxygenation was normal in both groups, and similar between groups throughout TH. Providing MEN during TH appears safe and effective, resulting in several important clinical benefits.

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一项前瞻性研究描述了在治疗性低温期间接受最低限度肠内营养的脑病新生儿内脏NIRS和临床结果。

目的：比较治疗性低温（TH）期间接受最低限度肠内营养（MEN）和未接受最低限度肠内营养（MEN）的婴儿的区域内脏氧合（SrSO2）水平和临床结果。研究设计：一项前瞻性、干预性队列研究，在两个地区围产期中心（NCT05471336）建立历史对照组。结果：男性组（n = 40）和对照组（n = 40）的参与者人口统计学特征和临床疾病严重程度相似。没有明显的安全事件。两组的SrSO2水平均正常。接受MEN治疗的受试者经历了更短的中心线天数（5.8 v 6.9, p = 0.005）和更高的母乳喂养率（77% v 46%, p = 0.010），并且更快地实现了完全口服喂养（9.9 v 13.4天，p = 0.043）。结论：两组肺组织氧合正常，两组间氧合基本一致。在TH期间提供男性似乎是安全有效的，产生了几个重要的临床益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.