Disseminated fusariosis successfully treated with empirical liposomal amphotericin B and voriconazole combination followed by ocular therapy in an allogenic hematopoietic stem cell transplant recipient.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-04-12 DOI:10.2169/internalmedicine.4657-24

Yuya Kishida, Masahiro Sakaguchi, Tomoyuki Kunishige, Atsushi Takeyoshi, Taichiro Tokura, Kazuki Inai, Ryosuke Kinoshita, Toshio Ibaraki, Satoshi Yamanaka, Toshio Asayama, Shunsuke Yui, Satoshi Wakita, Hiroki Yamaguchi

引用次数: 0

Abstract

We report the case of a 61-year-old man with chronic myelomonocytic leukemia, who underwent unrelated peripheral blood stem cell transplantation. Fusariosis was suspected prior to identification of the fungal species, and voriconazole and liposomal amphotericin B combination therapy were administered. The patient developed fusarium-related endophthalmitis, accompanied by eye pain. Despite vitrectomy, the endophthalmitis was poorly controlled, and the left eye was enucleated. No recurrence of fusariosis was observed until death following multiple-organ failure due to steroid-resistant graft-versus-host disease.

查看原文本刊更多论文

经验性两性霉素B脂质体联合伏立康唑治疗弥散性镰状虫病成功一例同种异体造血干细胞移植受体眼部治疗。

我们报告的情况下，61岁的男子慢性髓单细胞白血病，谁接受无关外周血干细胞移植。在真菌种类鉴定之前怀疑镰孢菌病，并给予伏立康唑和两性霉素B脂质体联合治疗。患者出现镰状核相关的眼内炎，并伴有眼痛。尽管进行了玻璃体切除术，但眼内炎控制不佳，左眼去核。在因类固醇抵抗性移植物抗宿主病导致多器官衰竭而死亡之前，没有观察到镰孢病的复发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.