Astrocytic GPR37L1: A new guardian against the onset and chronicity of neuropathic pain.

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-04-16 DOI:10.1016/j.neuron.2025.03.013

Yuta Kohro, Makoto Tsuda

引用次数: 0

Abstract

In this issue of Neuron, Xu et al.¹ demonstrate that activating GPR37L1, a G-protein-coupled receptor that negatively regulates astrocytes, suppresses the onset and maintenance of neuropathic pain, an intractable chronic pain caused by nerve damage, thereby serving as a therapeutic target.

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星形胶质细胞GPR37L1：抗神经性疼痛发病和慢性的新守护者。

在本期《神经元》杂志上，Xu等人1证实，激活GPR37L1（一种负性调节星形胶质细胞的g蛋白偶联受体）可以抑制神经性疼痛（一种由神经损伤引起的顽固性慢性疼痛）的发生和维持，从而作为治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.