Association of Matrix Metalloproteinase-7 Genotypes With Nasopharyngeal Carcinoma Risk.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-05-01 DOI:10.21873/invivo.13935

Liang-Chun Shih, Shih-Wei Hsu, Kai-Yuan Chen, Che-Lun Hsu, Yen-Fang Liu, Yun-Chi Wang, Hou-Yu Shih, Wen-Shin Chang, DA-Tian Bau, Chia-Wen Tsai

{"title":"Association of Matrix Metalloproteinase-7 Genotypes With Nasopharyngeal Carcinoma Risk.","authors":"Liang-Chun Shih, Shih-Wei Hsu, Kai-Yuan Chen, Che-Lun Hsu, Yen-Fang Liu, Yun-Chi Wang, Hou-Yu Shih, Wen-Shin Chang, DA-Tian Bau, Chia-Wen Tsai","doi":"10.21873/invivo.13935","DOIUrl":null,"url":null,"abstract":"Background/aim: Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy influenced by Epstein-Barr virus (EBV) infection, genetic susceptibility, and environmental factors. Matrix metalloproteinase-7 (MMP-7), a key regulator of extracellular matrix remodeling, has been implicated in NPC progression. This study investigated the association between MMP-7 rs11568818 and rs11568819 genotypes and NPC susceptibility in a Taiwanese cohort consisted of 208 NPC cases and 416 cancer-free controls.Materials and methods: The genotypic patterns of MMP-7 rs11568818 and rs11568819 were revealed by utilizing PCR-RFLP methodology. In addition, the interaction between MMP-7 genotypes and lifestyle factors (including smoking, alcohol consumption, and betel quid chewing) was also analyzed in a stratified manner.Results: Genotypic distribution analysis of MMP-7 rs11568818 showed no significant association with NPC risk (p for trend=0.4641). Individuals carrying the AG (OR=1.22, 95%CI=0.79-1.90, p=0.4384) or GG (OR=1.74, 95%CI=0.52-5.79, p=0.5539) genotypes exhibited a modestly elevated, but statistically non-significant, risk compared to AA carriers. Similarly, allelic frequency analysis indicated that the G allele did not significantly contribute to NPC susceptibility (OR=1.28, 95%CI=0.87-1.87, p=0.2433). Stratified analysis revealed a significant interaction between MMP-7 rs11568818 and smoking status (p for trend=0.0018). Among smokers, AG and GG genotypes were associated with an increased NPC risk (AG: OR=2.70, 95%CI=1.34-5.44, p=0.0076; GG: OR=9.27, 95%CI=1.01-84.66, p=0.0345), which remained significant after adjusting for confounders (adjusted OR=2.53, 95%CI=1.27-4.88; adjusted OR=7.89, 95%CI=1.02-47.38). No interactions were observed with alcohol consumption or betel quid chewing. Additionally, no polymorphic genotypes were detected for MMP-7 rs11568819 in the studied population.Conclusion: While MMP-7 rs11568818 does not directly influence NPC susceptibility in a Taiwanese population, its interaction with smoking may contribute to elevated NPC risk.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 3","pages":"1314-1324"},"PeriodicalIF":1.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041999/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"In vivo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/invivo.13935","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aim: Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy influenced by Epstein-Barr virus (EBV) infection, genetic susceptibility, and environmental factors. Matrix metalloproteinase-7 (MMP-7), a key regulator of extracellular matrix remodeling, has been implicated in NPC progression. This study investigated the association between MMP-7 rs11568818 and rs11568819 genotypes and NPC susceptibility in a Taiwanese cohort consisted of 208 NPC cases and 416 cancer-free controls.

Materials and methods: The genotypic patterns of MMP-7 rs11568818 and rs11568819 were revealed by utilizing PCR-RFLP methodology. In addition, the interaction between MMP-7 genotypes and lifestyle factors (including smoking, alcohol consumption, and betel quid chewing) was also analyzed in a stratified manner.

Results: Genotypic distribution analysis of MMP-7 rs11568818 showed no significant association with NPC risk (p for trend=0.4641). Individuals carrying the AG (OR=1.22, 95%CI=0.79-1.90, p=0.4384) or GG (OR=1.74, 95%CI=0.52-5.79, p=0.5539) genotypes exhibited a modestly elevated, but statistically non-significant, risk compared to AA carriers. Similarly, allelic frequency analysis indicated that the G allele did not significantly contribute to NPC susceptibility (OR=1.28, 95%CI=0.87-1.87, p=0.2433). Stratified analysis revealed a significant interaction between MMP-7 rs11568818 and smoking status (p for trend=0.0018). Among smokers, AG and GG genotypes were associated with an increased NPC risk (AG: OR=2.70, 95%CI=1.34-5.44, p=0.0076; GG: OR=9.27, 95%CI=1.01-84.66, p=0.0345), which remained significant after adjusting for confounders (adjusted OR=2.53, 95%CI=1.27-4.88; adjusted OR=7.89, 95%CI=1.02-47.38). No interactions were observed with alcohol consumption or betel quid chewing. Additionally, no polymorphic genotypes were detected for MMP-7 rs11568819 in the studied population.

Conclusion: While MMP-7 rs11568818 does not directly influence NPC susceptibility in a Taiwanese population, its interaction with smoking may contribute to elevated NPC risk.

查看原文本刊更多论文

基质金属蛋白酶-7基因型与鼻咽癌风险的关系

背景/目的：鼻咽癌（NPC）是一种受eb病毒感染、遗传易感性和环境因素影响的多因素恶性肿瘤。基质金属蛋白酶-7 （MMP-7）是细胞外基质重塑的关键调节因子，与鼻咽癌的进展有关。本研究在台湾研究了MMP-7 rs11568818和rs11568819基因型与鼻咽癌易感性之间的关系，其中包括208例鼻咽癌病例和416例无癌对照。材料与方法：采用PCR-RFLP方法分析MMP-7 rs11568818和rs11568819的基因型。此外，还分层分析了MMP-7基因型与生活方式因素（包括吸烟、饮酒和咀嚼槟榔液）之间的相互作用。结果：基因型分布分析显示MMP-7 rs11568818与鼻咽癌风险无显著相关性（p趋势=0.4641）。携带AG （OR=1.22, 95%CI=0.79-1.90, p=0.4384）或GG （OR=1.74, 95%CI=0.52-5.79, p=0.5539）基因型的个体与AA携带者相比，风险略有升高，但统计学上不显著。同样，等位基因频率分析显示，G等位基因对鼻咽癌易感性没有显著影响（OR=1.28, 95%CI=0.87-1.87, p=0.2433）。分层分析显示MMP-7 rs11568818与吸烟状况之间存在显著的相互作用（p为趋势=0.0018）。在吸烟者中，AG和GG基因型与NPC风险增加相关(AG: OR=2.70, 95%CI=1.34-5.44, p=0.0076；GG: OR=9.27, 95%CI=1.01-84.66, p=0.0345)，校正混杂因素后仍然显著(校正后OR=2.53, 95%CI=1.27-4.88；调整OR=7.89, 95%CI=1.02-47.38)。没有观察到与饮酒或咀嚼槟榔液的相互作用。此外，在研究人群中未检测到MMP-7 rs11568819的多态性基因型。结论：虽然MMP-7 rs11568818并不直接影响台湾人群鼻咽癌的易感性，但其与吸烟的相互作用可能会增加鼻咽癌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.