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Functional genomics identifies a protective role for FDX1 in atherosclerosis

IF 10.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Nature cardiovascular research Pub Date : 2025-05-13 DOI:10.1038/s44161-025-00636-y
Nicole Wayne, Marie A. Guerraty
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Abstract

A multi-omics study in the Health for Life in Singapore (HELIOS) study uncovered novel associations among rs10488763, FDX1, the reverse cholesterol-transport pathway, and atheroprotection. This elegant functional genomics study illustrates the potential of integrated ‘-omics’ to uncover novel pathways and potential therapeutic targets.

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功能基因组学鉴定了FDX1在动脉粥样硬化中的保护作用。
新加坡健康生命研究（HELIOS）的一项多组学研究揭示了rs10488763、FDX1、胆固醇逆向转运途径和动脉粥样硬化保护之间的新关联。这项优雅的功能基因组学研究说明了整合“组学”在发现新途径和潜在治疗靶点方面的潜力。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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来源期刊
Nature cardiovascular research
Nature cardiovascular research
CiteScore
5.70
自引率
0.00%
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0
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