Renal cell cancer treatment: the Latin American Cooperative Oncology Group (LACOG) and the Latin American Renal Cancer Group (LARCG) surgery-focused consensus update.

IF 2.6 4区 医学 Q2 UROLOGY & NEPHROLOGY
Therapeutic Advances in Urology Pub Date : 2025-04-14 eCollection Date: 2025-01-01 DOI:10.1177/17562872241312581
Stênio de Cássio Zequi, Anderson de Oliveira Galvão, André Costa Matos, Gilberto Laurino Almeida, Marcelo Esteves Chaves Campos, Marcelo Langer Wroclawski, Thiago Camelo Mourão, Wagner Eduardo Matheus, Arie Carneiro, Augusto Modesto de Sousa Neto, Aurus Meneses, Breno Dauster, Daher Cezar Chade, Deusdedit Cortez Vieira da Silva Neto, Éder Silveira Brazão, Eduardo Café Cardoso Pinto, Eliney Faria, Felipe de Almeida E Paula, Felipe Lott, Fernando Korkes, Fernando Meyer, Francisco Hidelbrando Alves Mota Filho, Frederico Mascarenhas, Giuliano Betoni Guglielmetti, Guilherme Antônio Veloso Coaracy, Gustavo Cardoso Guimarães, Gustavo Franco Carvalhal, Jonatas Luiz Pereira, Leandro Koifman, Lucas Fornazieri, Lucas Nogueira, Lucas Teixeira Batista, Luciano Alves Favorito, Luiz Henrique Araújo, Marcos Lima de Oliveira Leal, Marcos Tobias-Machado, Mauricio Cordeiro, Mauricio Murce Rocha, Nilo Jorge Carvalho Leão Filho, Rafael Ribeiro Meduna, Renato Beluco Corradi, Ricardo de Lima Favaretto, Roberto Machado, Rodolfo Borges Dos Reis, Roni de Carvalho Fernandes, Victor Espinheira Santos, Vladmir Pinheiro De Oliveira, Walter Henriques da Costa, Wilson F S Busato, Andrey Soares
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引用次数: 0

Abstract

Renal cell carcinoma (RCC) represents 2.2% of all malignancies worldwide; however, its mortality rate is not negligible. Surgery is the primary treatment for most nonadvanced cases, with its indications and techniques evolving over the years. To provide an update on RCC management in Brazil, focusing on surgery. The Latin American Cooperative Oncology Group-Genitourinary Section and the Latin American Renal Cancer Group gathered a panel of Brazilian urologists and clinical oncologists to vote on and discuss the best management of surgically resectable RCC. The experts compared the results with the literature and graded them according to the level of evidence. For small renal masses (SRMs; less than 4 cm), biopsy is indicated for specific/select cases, and when intervention is needed, partial nephrectomy should be prioritized. Radical nephrectomy and ablative techniques are exceptions for managing SRMs. Patients with small tumors (less than 3 cm), slow tumor growth, or a risk for surgery may benefit from active surveillance. Localized carcinoma up to 7 cm in diameter should be treated preferably with partial nephrectomy. Lymphadenectomy and adrenalectomy should be performed in locally advanced cases if involvement is suspected by imaging exams. Patients with venous tumor thrombi usually require surgical intervention depending on the extent of the thrombus. Neoadjuvant therapy should be considered for unresectable cases. Even in the era of targeted therapy, cytoreductive nephrectomy still has a role in metastatic disease. Metastasectomy is indicated for most patients with resectable disease. This consensus presents recommendations for surgical treatment of RCC based on expert opinions and evidence from the medical literature. Surgery remains the best curative option for nonadvanced cases, and it still has a role for select patients with metastatic disease.

肾细胞癌治疗:拉丁美洲肿瘤合作组(LACOG)和拉丁美洲肾癌组(LARCG)手术重点共识更新。
肾细胞癌(RCC)占全球所有恶性肿瘤的2.2%;然而,它的死亡率是不可忽视的。手术是大多数非晚期病例的主要治疗方法,其适应症和技术多年来不断发展。提供巴西RCC管理的最新情况,重点是手术。拉丁美洲合作肿瘤学组泌尿生殖科和拉丁美洲肾癌组聚集了一个由巴西泌尿科医生和临床肿瘤学家组成的小组,对手术切除肾细胞癌的最佳治疗进行投票和讨论。专家们将研究结果与文献进行了比较,并根据证据的程度进行了评分。对于小肾肿块(SRMs);小于4cm),对于特定/选择的病例需要活检,当需要干预时,应优先进行部分肾切除术。根治性肾切除术和消融技术是治疗srm的例外。小肿瘤(小于3cm)、肿瘤生长缓慢或有手术风险的患者可能受益于主动监测。对于直径达7厘米的局部癌,最好行部分肾切除术。如果影像学检查怀疑局部晚期病例受累,应行淋巴结切除术和肾上腺切除术。静脉肿瘤血栓患者通常需要手术治疗,这取决于血栓的范围。对于不能切除的病例应考虑新辅助治疗。即使在靶向治疗的时代,细胞减减性肾切除术仍然在转移性疾病中发挥作用。对于大多数可切除疾病的患者,转移瘤切除术是指的。这一共识提出了基于专家意见和医学文献证据的RCC手术治疗建议。对于非晚期病例,手术仍然是最好的治疗选择,对于转移性疾病患者,手术仍然有一定的作用。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
39
审稿时长
10 weeks
期刊介绍: Therapeutic Advances in Urology delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of urology. The journal has a strong clinical and pharmacological focus and is aimed at clinicians and researchers in urology, providing a forum in print and online for publishing the highest quality articles in this area. The editors welcome articles of current interest across all areas of urology, including treatment of urological disorders, with a focus on emerging pharmacological therapies.
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