Incidence of Osteopenia or Osteoporosis in Asian Patients With Chronic Hepatitis B

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Gastroenterology and Hepatology Pub Date : 2025-05-01 DOI:10.1111/jgh.16982

Hye Won Lee, Sungshin Kwon, Yeo Rae Moon, Hyunjung Ahn, Juyeon Lee, Sang-Hoon Ahn

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引用次数: 0

Abstract

Background

In an aging population, patients with chronic hepatitis B (CHB) may face a higher risk of osteopenia, osteoporosis, or fractures. We investigated the epidemiology and risk factors associated with osteopenia or osteoporosis in patients with CHB.

Methods

This retrospective cohort study included patients ≥ 19 years who underwent bone mineral density (BMD) testing ≥ 2 times between 2005 and 2021 at Severance Hospital, Seoul, South Korea. Demographic factors and comorbidities for patients with or without CHB were matched based on a 1:4 ratio. Cox proportional hazard regression models were used to estimate hazard ratios to assess osteopenia or osteoporosis risk.

Results

A total of 275 patients with CHB and 7868 patients without CHB who had normal BMD were analyzed. The incidence of osteopenia or osteoporosis in patients with and without CHB was 25.8% and 28.7%, respectively. After propensity score matching, in the second BMD test, 73.8%, 24.7%, and 1.5% of patients with CHB and 70.7%, 26.5%, and 2.8% of patients without CHB had normal BMD, osteopenia, and osteoporosis, respectively. Risk factors for osteopenia or osteoporosis in these patients were age, body mass index < 25, chronic kidney disease, and proton pump inhibitor use. There were no significant differences in cumulative hazard for patients with or without CHB.

Conclusions

Patients with or without CHB showed similar risks of osteopenia or osteoporosis. In addition to providing closer monitoring for patients with CHB with greater bone disease risk, further studies of bone disease in these patients may help to understand the factors that impact bone health.

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亚洲慢性乙型肝炎患者骨质疏松或骨质减少的发生率

背景：在老龄化人群中，慢性乙型肝炎（CHB）患者可能面临骨质减少、骨质疏松或骨折的高风险。我们调查了慢性乙型肝炎患者骨质减少或骨质疏松的流行病学和相关危险因素。方法：本回顾性队列研究纳入了2005年至2021年间在韩国首尔Severance医院接受骨矿物质密度（BMD）检测≥2次的≥19岁患者。根据1:4的比例匹配有或无慢性乙型肝炎患者的人口学因素和合并症。Cox比例风险回归模型用于评估骨质减少或骨质疏松风险的风险比。结果：共分析了骨密度正常的慢性乙型肝炎患者275例和非慢性乙型肝炎患者7868例。CHB患者和非CHB患者骨质减少或骨质疏松的发生率分别为25.8%和28.7%。在倾向评分匹配后，在第二次骨密度测试中，73.8%、24.7%和1.5%的慢性乙型肝炎患者和70.7%、26.5%和2.8%的非慢性乙型肝炎患者骨密度正常、骨质减少和骨质疏松。结论：伴有或不伴有CHB的患者出现骨质减少或骨质疏松的风险相似。除了为具有较高骨病风险的慢性乙型肝炎患者提供更密切的监测外，对这些患者骨病的进一步研究可能有助于了解影响骨骼健康的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastroenterology and Hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.40%

发文量

326

审稿时长

2.3 months

期刊介绍： Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.