Use of the CHA2DS2-VASc Score to Predict Concurrent Critical Coronary Artery Stenosis in Patients with Severe Carotid Artery Disease.

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Nigerian Journal of Clinical Practice Pub Date : 2025-04-01 Epub Date: 2025-04-26 DOI:10.4103/njcp.njcp_759_24

O Baran, Y Yilmaz, S Inci, Z Cetinkaya, S Kelesoglu

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Abstract

Background: There is a significant correlation between the severity of atherosclerosis in one arterial region and the occurrence of atherosclerotic disease in other regions. Identifying and managing vascular disease in patients with multifocal arterial disease is often complex. The CHA2DS2-VASc score encompasses several cardiovascular risk factors and was initially used to assess the risk of thromboembolism, stroke, and death in patients with atrial fibrillation. In recent years, this score has been proposed to predict the prognosis of various cardiovascular diseases.

Aim: The study aimed to investigate the prevalence of concomitant coronary artery disease (CAD) and the correlation between the CHA2DS2-VASc score and CAD in patients who were scheduled for carotid stenting due to carotid artery stenosis (CAS) but had no history of CAD.

Methods: A total of 452 patients were included in the study, 213 with symptomatic CAS and 239 with asymptomatic CAS. The patients were separated into two groups: those with and without.

Results: One hundred forty-eight (32.7%) of 452 patients had critical CAD. Multivariate logistic regression analysis showed that a high CHA2DS2-VASc score (OR: 4.283, 95% CI: 2.903-6.321, P < 0.001) was an independent predictor of the development of CAD. Receiver operating characteristic curve (ROC) analysis showed 64.9% sensitivity and 82% specificity in detecting CAD of the CHA2DS2-VASc score at >4 cutoff [Area under ROC curve = 0.781 (95% CI: 0.724-0.838), P < 0.001].

Conclusion: When our results were analyzed, a CHA2DS2-VASc score of >4 was highly significant in predicting severe CAD.

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应用CHA2DS2-VASc评分预测严重颈动脉疾病患者并发危重冠状动脉狭窄

背景：某一动脉区域动脉粥样硬化的严重程度与其他区域动脉粥样硬化性疾病的发生有显著相关性。多灶性动脉疾病患者血管疾病的识别和治疗往往是复杂的。CHA2DS2-VASc评分包括几个心血管危险因素，最初用于评估房颤患者血栓栓塞、中风和死亡的风险。近年来，该评分被用来预测各种心血管疾病的预后。目的：本研究旨在探讨无冠心病病史但因颈动脉狭窄（CAS）而行颈动脉支架置入术患者伴发冠心病（CAD）的发生率及CHA2DS2-VASc评分与CAD的相关性。方法：共纳入452例患者，其中有症状性CAS 213例，无症状性CAS 239例。患者被分为两组：有和没有。结果：452例患者中148例（32.7%）有危重性CAD。多因素logistic回归分析显示，高CHA2DS2-VASc评分（OR: 4.283, 95% CI: 2.903-6.321, P < 0.001）是CAD发展的独立预测因子。受试者工作特征曲线（ROC）分析显示，CHA2DS2-VASc评分在bbbb4截止点检测CAD的灵敏度为64.9%，特异性为82% [ROC曲线下面积= 0.781 (95% CI: 0.724-0.838), P < 0.001]。结论：对我们的结果进行分析时，CHA2DS2-VASc评分bbbb4在预测严重CAD方面具有高度意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-

CiteScore

1.40

自引率

0.00%

发文量

275

审稿时长

4-8 weeks

期刊介绍： The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.