S Karakaya, Y Kumtepe, R A Al, Gnc Senocak, Ept Yılmaz
{"title":"A Randomized Trial of Stair-Step Letrozole versus Traditional Letrozole for Subfertile Women with Polycystic Ovary Syndrome.","authors":"S Karakaya, Y Kumtepe, R A Al, Gnc Senocak, Ept Yılmaz","doi":"10.4103/njcp.njcp_516_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Traditional letrozole or clomiphene treatment is started on cycle days 3 to 5, following a spontaneous menses or progestin-induced bleeding. If ovulation does not occur, the dose is increased following a progestin-induced bleeding. An alternative stair step protocol has been described, and if ovulation does not occur in this protocol, a higher dose is used without inducing withdrawal bleeding. There is no randomized trial comparing the traditional and stair-step letrozole protocols yet.</p><p><strong>Aim: </strong>To compare the efficacy of traditional and stair-step protocols for ovulation induction using letrozole in women with polycystic ovary syndrome (PCOS).</p><p><strong>Methods: </strong>A total of 200 eligible women were given 5 mg/day letrozole, and those 80 who did not respond were randomized in a 1:1 ratio to stair-step or traditional letrozole therapy for up to 10 mg/day. For the traditional protocol, higher doses of letrozole were used in each new cycle if no ovulation occurred. For the stair-step protocol, higher doses of letrozole were given 7 days after the last dose if no dominant follicles were seen on ultrasonography. The PCOS was defined according to modified Rotterdam criteria. Participants were 18 to 35 years of age, had a body mass index of <40 kg/m2, had at least one patent fallopian tube, had a normal uterine cavity, and had normal spermiogram results.</p><p><strong>Results: </strong>The median follicle development time was significantly longer in the traditional protocol group than in the stair-step protocol group (41 days, 95% CI (40-42) vs 25 days, 95% CI (25-26); log rank 64; P < 0.001). Between traditional and stair step groups, the cumulative ovulation ratio (37/40 [%93] vs 36/40 [%90]; P = 1), endometrial thickness (9 [5-13] vs. 9 [5-11]; P = 0.005), mature follicule development (36/40 [%90] vs 36/40 [%90]; P = 0.549), pregnancy rates (3/40 [%8] vs 2/40 [%5]; P = 1), and antiestrogenic side effects were similar.</p><p><strong>Conclusions: </strong>The stair-step protocol shortens the treatment time without causing any detrimental effects on ovulation outcome.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"502-507"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/njcp.njcp_516_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Traditional letrozole or clomiphene treatment is started on cycle days 3 to 5, following a spontaneous menses or progestin-induced bleeding. If ovulation does not occur, the dose is increased following a progestin-induced bleeding. An alternative stair step protocol has been described, and if ovulation does not occur in this protocol, a higher dose is used without inducing withdrawal bleeding. There is no randomized trial comparing the traditional and stair-step letrozole protocols yet.
Aim: To compare the efficacy of traditional and stair-step protocols for ovulation induction using letrozole in women with polycystic ovary syndrome (PCOS).
Methods: A total of 200 eligible women were given 5 mg/day letrozole, and those 80 who did not respond were randomized in a 1:1 ratio to stair-step or traditional letrozole therapy for up to 10 mg/day. For the traditional protocol, higher doses of letrozole were used in each new cycle if no ovulation occurred. For the stair-step protocol, higher doses of letrozole were given 7 days after the last dose if no dominant follicles were seen on ultrasonography. The PCOS was defined according to modified Rotterdam criteria. Participants were 18 to 35 years of age, had a body mass index of <40 kg/m2, had at least one patent fallopian tube, had a normal uterine cavity, and had normal spermiogram results.
Results: The median follicle development time was significantly longer in the traditional protocol group than in the stair-step protocol group (41 days, 95% CI (40-42) vs 25 days, 95% CI (25-26); log rank 64; P < 0.001). Between traditional and stair step groups, the cumulative ovulation ratio (37/40 [%93] vs 36/40 [%90]; P = 1), endometrial thickness (9 [5-13] vs. 9 [5-11]; P = 0.005), mature follicule development (36/40 [%90] vs 36/40 [%90]; P = 0.549), pregnancy rates (3/40 [%8] vs 2/40 [%5]; P = 1), and antiestrogenic side effects were similar.
Conclusions: The stair-step protocol shortens the treatment time without causing any detrimental effects on ovulation outcome.
期刊介绍：
The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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