Evaluating blue light impact on reconstructed human epidermis using laser speckle imaging.

IF 3 3区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Biomedical Optics Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI:10.1117/1.JBO.30.5.056001

Léa Habib, Léa Abi Nassif, Marie Abboud, Rime Michael-Jubeli, Ali Tfayli, Roger Lteif

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Abstract

Significance: Blue light exposure is ubiquitous in modern life, raising concerns about its potential impact on skin health.

Aim: We aim to explore the effects of blue light on the reconstructed human epidermis (RHE) using the speckle analysis technique.

Approach: RHE samples were irradiated with controlled doses of blue light (415 and 455 nm) at defined stages of their maturation. Following irradiation, speckle analysis was performed to assess the impact of blue light on the skin barrier.

Results: Our results demonstrate that blue light irradiation significantly alters the scattering properties of RHE. Both wavelengths induced changes in the degree of linear polarization and speckle grain size, indicating disruptions in the skin barrier's structure and organization. The effects were found to be wavelength-dependent, with 455 nm irradiation showing more pronounced changes.

Conclusions: Speckle imaging allowed detection of changes in the scattering properties of RHE. Findings suggest that blue light exposure can influence skin barrier function and may have implications for skin health and related conditions.

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激光散斑成像评价蓝光对重建人体表皮的影响。

意义：蓝光暴露在现代生活中无处不在，它对皮肤健康的潜在影响引起了人们的关注。目的：利用斑点分析技术探讨蓝光对人体重建表皮（RHE）的影响。方法：RHE样品在其成熟的特定阶段用控制剂量的蓝光（415和455nm）照射。照射后，进行斑点分析以评估蓝光对皮肤屏障的影响。结果：我们的研究结果表明，蓝光照射显著改变了RHE的散射特性。这两种波长都会引起线极化程度和斑点颗粒大小的变化，表明皮肤屏障的结构和组织受到破坏。研究发现，这种影响与波长有关，455nm的辐射表现出更明显的变化。结论：散斑成像可以检测RHE散射特性的变化。研究结果表明，蓝光照射会影响皮肤屏障功能，并可能对皮肤健康和相关疾病产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Optics 医学-光学

CiteScore

6.40

自引率

5.70%

发文量

263

审稿时长

2 months

期刊介绍： The Journal of Biomedical Optics publishes peer-reviewed papers on the use of modern optical technology for improved health care and biomedical research.