Exact radiological-pathological correlation of chondrosarcomas using a patient-specific 3D mold.

IF 1.9 3区医学 Q2 ORTHOPEDICS

Skeletal Radiology Pub Date : 2025-05-13 DOI:10.1007/s00256-025-04942-1

Maryse Lejoly, Thomas Van Den Berghe, David Creytens, Wouter Huysse, Gwen Sys, Renaat Coopman, Koenraad L Verstraete

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引用次数: 0

Abstract

Objective: To identify aggressive regions in high-grade and dedifferentiated chondrosarcomas on MRI by obtaining an exact correlation between radiology and histopathology.

Materials and methods: One chondrosarcoma grade II (CSII), chondrosarcoma grade III (CSIII) and dedifferentiated chondrosarcoma (DDCS) were segmented on (DCE-)MRI images. Around the segmentations, a patient specific mold was constructed and 3D-printed with cutting grooves perfectly aligned with selected MRI slices. In this way, resection specimens could be cut at the same locations as the MRI slices. Histopathology slides were stained with hematoxylin-eosin and CD31 (vascularization) and correlated with the (DCE-)MRI. Histopathologically, atypical cartilaginous tumor (ACT), CSII, CSIII and DDCS regions were delineated and vascular hotspots were selected by an experienced pathologist. Exact point-to-point correlation was performed.

Results: ACT, CSII, CSIII and DDCS regions all had similar mean signal intensity on T1-weighted images. On fat-saturated T2-weigthed images, CSII and CSIII regions had a higher mean signal intensity. On fat-saturated T1-weighted images after gadolinium contrast injection and on wash-in parametric maps DDCS regions had the highest mean signal intensity and highest wash-in values. There was a higher microvessel density in CSII and CSIII regions. This corresponded with a thick enhancing rim on fat-saturated T1-weighted images after gadolinium contrast injection and with a higher wash-in.

Conclusion: This new 3D mold helps to identify high-grade chondrosarcoma regions with myxoid. This may be useful for targeted biopsy and histopathological investigation.

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使用患者特异性3D模具的软骨肉瘤的精确放射学-病理学相关性。

目的：在MRI上鉴别高级别软骨肉瘤和去分化软骨肉瘤的侵袭区，以获得影像学和组织病理学的精确相关性。材料与方法：在（DCE-）MRI图像上对1例II级软骨肉瘤（CSII）、III级软骨肉瘤（CSIII）和去分化软骨肉瘤（DDCS）进行分割。在分割周围，构建了一个患者特定的模具，并通过3d打印将切割凹槽与选定的MRI切片完美对齐。这样，切除标本可以在与MRI切片相同的位置切割。组织病理学切片采用苏木精-伊红染色和CD31（血管化）染色，并与（DCE-）MRI相关。组织病理学上，由经验丰富的病理学家划定非典型软骨瘤（ACT）、CSII、CSIII和DDCS区域，并选择血管热点。进行了精确的点对点相关。结果：ACT、CSII、CSIII和DDCS区域在t1加权图像上的平均信号强度相似。在脂肪饱和的t2加权图像上，CSII和CSIII区域的平均信号强度更高。在注射钆造影剂后脂肪饱和的t1加权图像和洗入参数图上，DDCS区域的平均信号强度和洗入值最高。CSII区和CSIII区微血管密度较高。这与注射钆造影剂后脂肪饱和t1加权图像上的厚增强边缘相对应，并且具有较高的冲洗率。结论：这种新的三维模型有助于鉴别高级别软骨肉瘤黏液样区。这可能对靶向活检和组织病理学调查有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Skeletal Radiology 医学-核医学

CiteScore

4.40

自引率

9.50%

发文量

253

审稿时长

3-8 weeks

期刊介绍： Skeletal Radiology provides a forum for the dissemination of current knowledge and information dealing with disorders of the musculoskeletal system including the spine. While emphasizing the radiological aspects of the many varied skeletal abnormalities, the journal also adopts an interdisciplinary approach, reflecting the membership of the International Skeletal Society. Thus, the anatomical, pathological, physiological, clinical, metabolic and epidemiological aspects of the many entities affecting the skeleton receive appropriate consideration. This is the Journal of the International Skeletal Society and the Official Journal of the Society of Skeletal Radiology and the Australasian Musculoskelelal Imaging Group.