{"title":"Vitamin D receptor gene polymorphism in oral cancer as a function of tobacco consumption: an evidence based systematic review and meta-analysis.","authors":"Tribikram Debata, Amrita Swain, Soumya Ranjan Jena, Surya Narayan Das, Niranjan Mishra, Luna Samanta","doi":"10.3389/froh.2025.1550683","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the influence of VDR gene variants on the development of tobacco-related oral cancer, emphasizing genetic underpinnings of individual vulnerability and possible tailored preventative approaches.</p><p><strong>Materials and methods: </strong>The search strategy for this systematic review and meta-analysis was devised to comprehensively identify relevant studies from diverse sources. The investigation included three primary components: the VDR gene, oral cancer, and tobacco. The data from the papers included in the study were independently retrieved by two reviewers. The incidence was evaluated as an odds ratio (OR) with 95% confidence interval (95% CI) using SPSS software.</p><p><strong>Results: </strong>A preliminary search of biomedical electronic research databases (PubMed, Web of Science, Scopus, Embase, and the Cochrane Library) yielded 60,345 papers. After multi-phase exclusions, five studies met the inclusion criteria. The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. The CYP24A1 (rs2296241) heterozygote genotype significantly reduces oral cancer risk (OR = 0.281, <i>P</i> = 0.00001). Variants rs1544410 and rs2228570 influence oral health outcomes. The rs2239185 TT (OR = 2.68, <i>P</i> = 0.009) and rs7975232 CC (OR = 2.25, <i>P</i> = 0.026) increase oral lichen planus risk. Older age is significantly linked to OSCC risk (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>This research underscores the role of VDR gene variants in tobacco-related oral cancer. Further studies are essential to validate findings and explore underlying mechanisms.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024587292, identifier: CRD42024587292.</p>","PeriodicalId":94016,"journal":{"name":"Frontiers in oral health","volume":"6 ","pages":"1550683"},"PeriodicalIF":3.0000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066760/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in oral health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/froh.2025.1550683","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The association between Vitamin D Receptor (VDR) polymorphisms and different cancers has attracted growing attention; nonetheless, the function of these genetic variants in tobacco-related oral cancer remains little comprehended. This review assesses and integrates research concerning the influence of VDR gene variants on the development of tobacco-related oral cancer, emphasizing genetic underpinnings of individual vulnerability and possible tailored preventative approaches.
Materials and methods: The search strategy for this systematic review and meta-analysis was devised to comprehensively identify relevant studies from diverse sources. The investigation included three primary components: the VDR gene, oral cancer, and tobacco. The data from the papers included in the study were independently retrieved by two reviewers. The incidence was evaluated as an odds ratio (OR) with 95% confidence interval (95% CI) using SPSS software.
Results: A preliminary search of biomedical electronic research databases (PubMed, Web of Science, Scopus, Embase, and the Cochrane Library) yielded 60,345 papers. After multi-phase exclusions, five studies met the inclusion criteria. The meta-analysis highlights interactions between genetic polymorphisms, smoking, aging, and oral health risks. The CYP24A1 (rs2296241) heterozygote genotype significantly reduces oral cancer risk (OR = 0.281, P = 0.00001). Variants rs1544410 and rs2228570 influence oral health outcomes. The rs2239185 TT (OR = 2.68, P = 0.009) and rs7975232 CC (OR = 2.25, P = 0.026) increase oral lichen planus risk. Older age is significantly linked to OSCC risk (P = 0.001).
Conclusion: This research underscores the role of VDR gene variants in tobacco-related oral cancer. Further studies are essential to validate findings and explore underlying mechanisms.
背景：维生素D受体（VDR）多态性与不同癌症之间的关系越来越受到关注；然而，这些基因变异在烟草相关口腔癌中的作用仍然知之甚少。本综述评估并整合了有关VDR基因变异对烟草相关口腔癌发展影响的研究，强调了个体易感性的遗传基础和可能的量身定制的预防方法。材料和方法：本系统综述和荟萃分析的检索策略旨在全面识别来自不同来源的相关研究。调查包括三个主要组成部分：VDR基因、口腔癌和烟草。纳入研究的论文数据由两位审稿人独立检索。使用SPSS软件以95%置信区间（95% CI）的比值比（OR）评估发生率。结果：对生物医学电子研究数据库（PubMed, Web of Science, Scopus， Embase和Cochrane Library）的初步搜索产生了60345篇论文。经过多期排除，有5项研究符合纳入标准。荟萃分析强调了遗传多态性、吸烟、衰老和口腔健康风险之间的相互作用。CYP24A1 （rs2296241）杂合子基因型显著降低口腔癌风险（OR = 0.281, P = 0.00001）。变异rs1544410和rs2228570影响口腔健康结果。rs2239185 TT （OR = 2.68, P = 0.009）和rs7975232 CC （OR = 2.25, P = 0.026）增加口腔扁平苔藓的风险。年龄与OSCC风险显著相关（P = 0.001）。结论：本研究强调了VDR基因变异在烟草相关口腔癌中的作用。进一步的研究对验证研究结果和探索潜在机制至关重要。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD42024587292，标识符：CRD42024587292。
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