A review of Babesiosis caused by Babesia ovis in small ruminants.

Abstract

Babesiosis is a significant tick-borne disease that impacts both domestic and wild animals, as well as humans, with its prevalence being particularly high in tropical and subtropical areas. Among small ruminants, Babesia ovis is a leading cause of babesiosis, especially in areas where Rhipicephalus bursa ticks are prevalent. The transmission of the disease occurs through tick bites, imposing a considerable economic strain on livestock industries in regions where it is prevalent. Clinical manifestations of the disease include hemolytic anemia, fever, jaundice, lethargy, anorexia, weight loss, and, in some cases, hemoglobinuria. A key aspect of babesiosis pathogenesis is the oxidative stress it induces in the host. For diagnosis, polymerase chain reaction (PCR) has emerged as the most sensitive and specific method, surpassing traditional diagnostic approaches like blood smears and serological testing. The treatment of choice for B. ovis infections in sheep is imidocarb dihydrochloride, which is administered in divided doses of 2 mg/kg. This treatment has proven effective in eradicating the parasite without relapse. Alternative treatments, such as aromatic diamidines, are associated with several drawbacks, including adverse effects and incomplete parasite clearance. Currently, diminazene aceturate and imidocarb dipropionate are widely employed babesiacidal drugs. Efforts to prevent and control babesiosis focus primarily on tick management, the use of resistant livestock breeds, and vaccination. Tick control strategies have evolved significantly, moving from traditional chemical dips to the use of systemic acaricides and self-treatment devices. Furthermore, non-chemical interventions, such as environmental management and selective breeding for tick resistance, are increasingly recognized as vital components of a comprehensive prevention strategy. This review provides an in-depth examination of the life cycle, epidemiology, risk factors, diagnostic methods, treatment options, and prevention strategies for B. ovis infection in small ruminants.