Lesion Mimic Mutant: An Ideal Genetic Material for Deciphering the Balance Between Plant Immunity and Growth.

IF 4.8 1区 农林科学 Q1 AGRONOMY
Rice Pub Date : 2025-05-13 DOI:10.1186/s12284-025-00789-1
Huilin Chen, Letong Liu, Qiguang Zhou, Yulin Zhu, Ziwen Gao, Taotao Zhu, Jie Huang, Mengxue Du, Yong Song, Lingzhi Meng
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Abstract

Lesion mimic mutants (LMMs) form hypersensitive response (HR)-like lesions, a form of programmed cell death (PCD), in the absence of pathogens, that often confer durable and broad-spectrum disease resistance, representing a potential source for breeding resistance. However, most LMM plants have significant growth retardation including cell death, leaf senescence, damaged chloroplast structure, decreased chlorophyll contents, and undesirable agronomic traits. Therefore, LMMs represent ideal genetic materials to decipher interactions between defense signaling and programmed cell death, and growth. Many LMMs have been identified in rice, and at least 61 genes have been cloned and functionally confirmed. LMM genes are reported to participate in various regulation pathways, including gene transcription and protein translation, ubiquitin-proteasome pathway, protein phosphorylation, vesicle trafficking, metabolic pathways, and phytohormone signaling, highlighting the complexity of regulatory mechanisms. This review discusses recent progress on characteristics of rice LMM and mechanisms of LMM gene regulation, and suggests directions for future theoretical research and the potential use of LMMs in rice breeding.

病变模拟突变体:破译植物免疫与生长平衡的理想遗传物质。
病变模拟突变体(lmm)在没有病原体的情况下形成超敏反应(HR)样病变,这是一种程序性细胞死亡(PCD)形式,通常赋予持久和广谱的疾病抗性,代表了育种抗性的潜在来源。然而,大多数LMM植物存在明显的生长迟缓,包括细胞死亡、叶片衰老、叶绿体结构受损、叶绿素含量下降和农艺性状不良。因此,lmm代表了理想的遗传物质来破译防御信号与程序性细胞死亡和生长之间的相互作用。在水稻中已经发现了许多lmm,至少有61个基因已经被克隆并在功能上得到证实。据报道,LMM基因参与多种调控途径,包括基因转录和蛋白质翻译、泛素-蛋白酶体途径、蛋白质磷酸化、囊泡运输、代谢途径和植物激素信号传导,突出了调控机制的复杂性。本文综述了水稻LMM基因的特性和调控机制,并对LMM基因在水稻育种中的应用前景和今后的理论研究方向进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rice
Rice AGRONOMY-
CiteScore
10.10
自引率
3.60%
发文量
60
审稿时长
>12 weeks
期刊介绍: Rice aims to fill a glaring void in basic and applied plant science journal publishing. This journal is the world''s only high-quality serial publication for reporting current advances in rice genetics, structural and functional genomics, comparative genomics, molecular biology and physiology, molecular breeding and comparative biology. Rice welcomes review articles and original papers in all of the aforementioned areas and serves as the primary source of newly published information for researchers and students in rice and related research.
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