Non-ST-Elevation Myocardial Infarction as the Initial Manifestation of Calreticulin-Positive Essential Thrombocythemia: A Case Report.

IF 2.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Development and Disease Pub Date : 2025-04-16 DOI:10.3390/jcdd12040157

Jared B Hinton, Jalal S Jwayyed, Sonum Jagetia, Hunter J Landwehr, John D Scrocco

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Abstract

Essential thrombocythemia (ET) is a rare myeloproliferative neoplasm characterized by excessive platelet production and a predisposition to thrombotic or hemorrhagic complications. We report a case of a 62-year-old male with no conventional cardiovascular risk factors who presented with a non-ST-segment elevation myocardial infarction (NSTEMI). Initial coronary angiography showed isolated proximal LAD stenosis. Laboratory tests revealed marked thrombocytosis (>1,000,000/μL) and a CALR mutation, confirming a diagnosis of ET. The patient was treated with percutaneous coronary intervention (PCI), dual antiplatelet therapy, and cytoreductive therapy with hydroxyurea, leading to a favorable outcome. This case illustrates how ET, particularly CALR-mutated subtypes, can manifest as acute coronary syndrome in the absence of atherosclerosis and underscores the need to consider hematologic malignancies in atypical presentations of myocardial infarction.

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非st段抬高型心肌梗死作为钙网蛋白阳性原发性血小板增多症的初始表现：1例报告。

原发性血小板增多症（ET）是一种罕见的骨髓增生性肿瘤，其特征是血小板产生过多，易发生血栓或出血性并发症。我们报告一例62岁男性无常规心血管危险因素谁提出了非st段抬高心肌梗死（NSTEMI）。初始冠状动脉造影显示孤立的LAD近端狭窄。实验室检查显示明显的血小板增多（bbb10 100万/μL）和CALR突变，确认ET的诊断。患者接受了经皮冠状动脉介入治疗（PCI）、双重抗血小板治疗和羟基脲细胞减少治疗，结果良好。本病例说明了ET，特别是calr突变亚型，如何在没有动脉粥样硬化的情况下表现为急性冠状动脉综合征，并强调了在非典型心肌梗死表现中考虑血液恶性肿瘤的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Development and Disease CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.60

自引率

12.50%

发文量

381