Kai Sun, Yunqi Liu, Yanshu Pan, Dongwei Di, Jianfang Li, Feiyun Xu, Li Li, Yoshiharu Mimata, Yingying Chen, Lixia Xie, Siqi Wang, Wenqian Qi, Yan Tang, Huachun Sheng, Bing Wang, Ruixue Sun, Dingquan Tan, Daohong Fu, Ye Yin, Ao Xue, Yichao Shi, Wenjing Shao, Lei Gong, Zhijian Jiang, Wei Zhang, Qiangsheng Wu, Yaosheng Wang, Minglin Lang, Wenxiu Ye, Weifeng Xu, Shuhe Wei, Weiming Shi, Yue Jeff Xu
{"title":"Non-invasive micro-test technology and applications.","authors":"Kai Sun, Yunqi Liu, Yanshu Pan, Dongwei Di, Jianfang Li, Feiyun Xu, Li Li, Yoshiharu Mimata, Yingying Chen, Lixia Xie, Siqi Wang, Wenqian Qi, Yan Tang, Huachun Sheng, Bing Wang, Ruixue Sun, Dingquan Tan, Daohong Fu, Ye Yin, Ao Xue, Yichao Shi, Wenjing Shao, Lei Gong, Zhijian Jiang, Wei Zhang, Qiangsheng Wu, Yaosheng Wang, Minglin Lang, Wenxiu Ye, Weifeng Xu, Shuhe Wei, Weiming Shi, Yue Jeff Xu","doi":"10.52601/bpr.2024.240009","DOIUrl":null,"url":null,"abstract":"<p><p>Non-invasive micro-test technology (NMT) reveals dynamic ionic/molecular concentration gradients by measuring fluxes of ions and small molecules in liquid media in 1D, 2D or 3D fashions with sensitivity up to pico- (10<sup>-12</sup>) or femto- (10<sup>-15</sup>) moles per cm<sup>2</sup> per second. NMT has been applied to study metabolism, signal transduction, genes and/or proteins physiological functions related to transmembrane ionic/molecular activities with live samples under normal conditions or stress. Data on ion and/or molecule homeostasis (IMH) by NMT in biomedical sciences, plant and crop sciences, environmental sciences, marine and space biology as well as traditional Chinese medicine are reviewed.</p>","PeriodicalId":93906,"journal":{"name":"Biophysics reports","volume":"11 2","pages":"96-111"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035745/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52601/bpr.2024.240009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Non-invasive micro-test technology (NMT) reveals dynamic ionic/molecular concentration gradients by measuring fluxes of ions and small molecules in liquid media in 1D, 2D or 3D fashions with sensitivity up to pico- (10-12) or femto- (10-15) moles per cm2 per second. NMT has been applied to study metabolism, signal transduction, genes and/or proteins physiological functions related to transmembrane ionic/molecular activities with live samples under normal conditions or stress. Data on ion and/or molecule homeostasis (IMH) by NMT in biomedical sciences, plant and crop sciences, environmental sciences, marine and space biology as well as traditional Chinese medicine are reviewed.
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