{"title":"Analysis of Differentially Expressed Proteins Involved in Shrimp and Crab Allergies.","authors":"Ruhong Tan, Xiwen Wei, Jiacheng Zhong, Yuanbin Wang, Qing Yu","doi":"10.1002/jcla.70053","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Shrimp and crab allergies have garnered increasing attention in recent years. Unlike many other food allergies, they are less likely to be outgrown by children and tend to trigger more severe allergic symptoms. The underlying mechanisms that lead to these phenomena have not yet been fully elucidated.</p><p><strong>Methods: </strong>We used proteomics iTRAQ technology to identify differentially expressed proteins in shrimp and crab allergic patients and normal controls.</p><p><strong>Results: </strong>Ninety differentially expressed proteins, including 82 upregulated proteins and 8 downregulated proteins, were identified. Furthermore, MRC2 was validated to be upregulated in shrimp and crab allergic patients by ELISA.</p><p><strong>Conclusion: </strong>These findings have established a comprehensive proteomics map of shrimp and crab allergies, laying the foundation for further analysis of the pathogenesis and regulatory network of shrimp and crab allergies.</p>","PeriodicalId":15509,"journal":{"name":"Journal of Clinical Laboratory Analysis","volume":" ","pages":"e70053"},"PeriodicalIF":2.6000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Laboratory Analysis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcla.70053","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Shrimp and crab allergies have garnered increasing attention in recent years. Unlike many other food allergies, they are less likely to be outgrown by children and tend to trigger more severe allergic symptoms. The underlying mechanisms that lead to these phenomena have not yet been fully elucidated.
Methods: We used proteomics iTRAQ technology to identify differentially expressed proteins in shrimp and crab allergic patients and normal controls.
Results: Ninety differentially expressed proteins, including 82 upregulated proteins and 8 downregulated proteins, were identified. Furthermore, MRC2 was validated to be upregulated in shrimp and crab allergic patients by ELISA.
Conclusion: These findings have established a comprehensive proteomics map of shrimp and crab allergies, laying the foundation for further analysis of the pathogenesis and regulatory network of shrimp and crab allergies.
期刊介绍：
Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.
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