Risk-adjusted trifecta outcomes in ultrasound-guided RFA of T1a renal masses: experi-ence from a large tertiary cancer center.

IF 4.5 3区 医学 Q1 UROLOGY & NEPHROLOGY
Derun Li, Jiyu Yang, Xiang Wang, Yi Liu, Gangzhi Shan, Zibo Zhang, Xu Han, Zhihua Li, Xuesong Li
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Abstract

Purpose: To evaluate the trifecta outcomes of ultrasound-guided radiofrequency ablation (RFA) of T1a renal masses and to identify factors influencing trifecta outcomes.

Materials and methods: We retrospectively reviewed data from patients who underwent ultrasound-guided RFA at Peking University First Hospital between March 2017 and May 2024. Baseline demographics, perioperative outcomes and follow-up results were collected. The trifecta outcomes were defined as the absence of severe complications, incomplete ablation and tumour recurrence. Multivariate logistic regression analysis was performed to identify risk factors for trifecta failure.

Results: Among 270 patients (140 left-sided and 130 right-sided), the median tumour size was 1.97 (range 0.80-3.86) cm, and 32 (11.9%) patients had a history of ipsilateral partial nephrectomy. During the median follow-up of 35.6 (range 6.2-91.4) months, the rates of severe complications, tumour recurrence, and incomplete ablation were 1.1%, 7.4%, and 7.4%, respectively. The trifecta outcome was achieved in 227 (84.1%) patients. Multivariate analysis revealed that tumour size [odds ratio (OR): 2.144, p = 0.007] and history of ipsilateral partial nephrectomy (OR: 3.894, p = 0.002) independently predicted trifecta failure.

Conclusion: Ultrasound-guided RFA is a safe and effective treatment for T1a renal masses. Tumour size and a history of ipsilateral partial nephrectomy were significantly associated with trifecta failure.

Abstract Image

Abstract Image

超声引导下RFA治疗T1a肾肿块的风险调整三联预后:来自大型三级癌症中心的经验。
目的:评价超声引导下射频消融(RFA)治疗T1a肾肿块的三联治疗效果,探讨影响三联治疗效果的因素。材料与方法:回顾性分析2017年3月至2024年5月北京大学第一医院超声引导RFA患者的资料。收集基线人口统计学、围手术期结局和随访结果。三合一结果定义为无严重并发症、不完全消融和肿瘤复发。进行多因素logistic回归分析以确定三联管失败的危险因素。结果:270例患者(140例左侧,130例右侧)中位肿瘤大小为1.97(范围0.80 ~ 3.86)cm, 32例(11.9%)患者有同侧部分肾切除术史。在中位随访35.6个月(6.2-91.4个月)期间,严重并发症、肿瘤复发率和不完全消融率分别为1.1%、7.4%和7.4%。227例(84.1%)患者获得了三合一结果。多因素分析显示,肿瘤大小[比值比(OR): 2.144, p = 0.007]和同侧部分肾切除术史(OR: 3.894, p = 0.002)独立预测三联切除失败。结论:超声引导下RFA治疗T1a肾肿块安全有效。肿瘤大小和同侧部分肾切除术史与三节切除失败显著相关。
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来源期刊
International Braz J Urol
International Braz J Urol UROLOGY & NEPHROLOGY-
CiteScore
4.60
自引率
21.60%
发文量
246
审稿时长
6-12 weeks
期刊介绍: Information not localized
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