PREGNANCY DISORDERS AND MATERNAL CONSEQUENCES: Emerging viral infections during pregnancy: understanding the risks to maternal and fetal health.

IF 3.7 3区生物学 Q1 DEVELOPMENTAL BIOLOGY

Reproduction Pub Date : 2025-04-25 Print Date: 2025-05-01 DOI:10.1530/REP-25-0043

Jessica A Neil

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引用次数: 0

Abstract

In brief: Emerging viral infections pose a significant risk to pregnant women and their offspring. This review summarizes what is known about maternal and fetal outcomes following infection with emerging viruses and discusses how we can prepare for the next outbreak.

Abstract: Viral infections during pregnancy pose significant risks to both maternal and fetal health. While several viruses are well known to cause adverse pregnancy outcomes, often little is known about emerging viruses. This review summarizes the known maternal and fetal consequences of infection during pregnancy with novel and re-emerging viruses. Focus is placed on viruses such as Zika and SARS-CoV-2, among others, discussing the mechanisms by which these viruses may disrupt fetal development at the maternal-fetal interface. The review also addresses the challenges that need to be overcome, such as the need for ongoing disease surveillance, prioritization of pregnant women for clinical trials and the importance of pre-clinical models of placenta infection, to adequately prepare for the next virus outbreak.

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妊娠疾病和孕产妇后果：妊娠期间新出现的病毒感染：了解对孕产妇和胎儿健康的风险。

简而言之：新出现的病毒感染对孕妇及其后代构成重大风险。本综述总结了感染新发病毒后孕产妇和胎儿结局的已知情况，并讨论了我们如何为下一次疫情做好准备。摘要：妊娠期病毒感染对孕产妇和胎儿健康都有重大风险。众所周知，有几种病毒会导致不良的妊娠结局，但人们对新出现的病毒往往知之甚少。本文综述了妊娠期感染新病毒和再出现病毒对母体和胎儿的已知后果。重点放在寨卡病毒和SARS-CoV-2等病毒上，讨论这些病毒可能在母胎界面破坏胎儿发育的机制。该审查还解决了需要克服的挑战，例如需要进行持续的疾病监测，优先考虑孕妇进行临床试验以及胎盘感染临床前模型的重要性，以便为下一次病毒爆发做好充分准备。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproduction 生物-发育生物学

CiteScore

7.40

自引率

2.60%

发文量

199

审稿时长

4-8 weeks

期刊介绍： Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.