Binary- and Three-Tiered Oral Epithelial Dysplasia Grading System and Malignant Transformation.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-15 DOI:10.1111/odi.15334

Riikka Ellonen, Jetta Kelppe, Jaana Hagström, Auli Suominen, Jaana Willberg, Jaana Rautava, Hanna K Laine

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引用次数: 0

Abstract

Objectives: Oral epithelial dysplasia (OED) can be graded histopathologically by using a binary- or three-tiered grading system. This study aimed to analyze and compare the prognostic value of the two systems in a large single-institute material.

Materials and methods: The study was a retrospective histopathological re-evaluation analysis of 612 OEDs over 29 years at the Institute of Dentistry, University of Turku, Turku, Finland. OED patients who later developed squamous cell carcinoma (OSCC) were identified from the Finnish Cancer Registry database.

Results: Altogether, the mean age of 612 OEDs patients was 59.9 years. The male:female ratio was 0.67. According to the original three-tiered diagnosis, 67.7% of the samples were mild dysplasia, 28.7% moderate dysplasia, and 3.6% severe dysplasia cases. With binary-tiered diagnosis, low-grade dysplasia 84.1% was more common than high-grade dysplasia 15.9%. The malignant transformation rate was 7.8%. Regarding oral SCC development, no difference was found between the grading systems in predicting the malignant progression (p = 0.060).

Conclusions: Both binary- and three-tiered grading systems of dysplasia classification had similar predictive value for malignant transformation.

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二、三级口腔上皮发育不良分级系统与恶性转化。

目的：口腔上皮性发育不良（OED）可以通过使用二层或三层分级系统进行组织病理学分级。本研究旨在分析和比较两种系统在大型单一研究所材料中的预后价值。材料和方法：本研究是对芬兰图尔库大学牙科研究所29年来612例oed的回顾性组织病理学再评估分析。从芬兰癌症登记数据库中确定后来发展为鳞状细胞癌（OSCC）的OED患者。结果：612例oed患者的平均年龄为59.9岁。男女比例为0.67。根据最初的三层诊断，67.7%的样本为轻度发育不良，28.7%为中度发育不良，3.6%为重度发育不良。分级诊断中，84.1%的低级别不典型增生比15.9%的高级别不典型增生更常见。恶性转化率为7.8%。对于口腔SCC的发展，两种分级系统在预测恶性进展方面没有差异（p = 0.060）。结论：非典型增生的二级和三级分级系统对恶性转化具有相似的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.