Diagnostic delay and misdiagnosis of symptoms reported by patients with multiple sclerosis participating in a research registry.

IF 2.5 Q2 CLINICAL NEUROLOGY
Andrew J Solomon, Sarah M Weinstein, Russell T Shinohara, Samar M Aoun, Hollie Schmidt, Alessandra Solari
{"title":"Diagnostic delay and misdiagnosis of symptoms reported by patients with multiple sclerosis participating in a research registry.","authors":"Andrew J Solomon, Sarah M Weinstein, Russell T Shinohara, Samar M Aoun, Hollie Schmidt, Alessandra Solari","doi":"10.1177/20552173251333390","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Research cohort data suggest diagnostic delay in multiple sclerosis (MS) has diminished in tandem with MS diagnostic criteria revisions, yet other studies have not replicated this finding. Recent data indicate misdiagnosis of initial symptoms of MS is a frequent contributor to diagnostic delay.</p><p><strong>Objectives: </strong>This survey study assessed diagnostic delay and misdiagnosis in an MS patient registry.</p><p><strong>Methods: </strong>Participants completed the survey study between November 12, 2021, through December 22, 2021.</p><p><strong>Results: </strong>There were 428 participants. Diagnostic delay was a median of 2.0 months (mean of 22.8 months, range: 0-32.9 years); 173/428 (40.4%) reported misdiagnosis of symptoms later attributed to MS, and this was associated with longer diagnostic delay (<i>p</i> < 0.001). Diagnostic delay decreased over time proximal to revisions to MS diagnostic criteria. 217/428 (50.7%) reported earlier symptoms retrospectively recognized as referable to MS that were not clinically evaluated, resulting in a diagnostic delay median of 5.4 years (mean 8.9 years, range: 0-47.4 years).</p><p><strong>Conclusions: </strong>Diagnostic delay was prevalent and associated with frequent misdiagnosis of initial symptoms of MS and earlier unevaluated symptoms later attributed to MS. Studies tracing the diagnostic journey of patients with MS are needed to understand and prevent causes of diagnostic delay.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"11 2","pages":"20552173251333390"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033781/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20552173251333390","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Research cohort data suggest diagnostic delay in multiple sclerosis (MS) has diminished in tandem with MS diagnostic criteria revisions, yet other studies have not replicated this finding. Recent data indicate misdiagnosis of initial symptoms of MS is a frequent contributor to diagnostic delay.

Objectives: This survey study assessed diagnostic delay and misdiagnosis in an MS patient registry.

Methods: Participants completed the survey study between November 12, 2021, through December 22, 2021.

Results: There were 428 participants. Diagnostic delay was a median of 2.0 months (mean of 22.8 months, range: 0-32.9 years); 173/428 (40.4%) reported misdiagnosis of symptoms later attributed to MS, and this was associated with longer diagnostic delay (p < 0.001). Diagnostic delay decreased over time proximal to revisions to MS diagnostic criteria. 217/428 (50.7%) reported earlier symptoms retrospectively recognized as referable to MS that were not clinically evaluated, resulting in a diagnostic delay median of 5.4 years (mean 8.9 years, range: 0-47.4 years).

Conclusions: Diagnostic delay was prevalent and associated with frequent misdiagnosis of initial symptoms of MS and earlier unevaluated symptoms later attributed to MS. Studies tracing the diagnostic journey of patients with MS are needed to understand and prevent causes of diagnostic delay.

参与研究登记的多发性硬化症患者报告的诊断延迟和误诊症状
背景:研究队列数据表明,多发性硬化症(MS)的诊断延迟随着MS诊断标准的修订而减少,但其他研究并未重复这一发现。最近的数据表明,误诊的初始症状的多发性硬化症是一个常见的贡献者诊断延误。目的:本调查研究评估了多发性硬化症患者的诊断延迟和误诊。方法:参与者在2021年11月12日至2021年12月22日之间完成调查研究。结果:共纳入428人。诊断延迟中位数为2.0个月(平均22.8个月,范围:0-32.9年);173/428(40.4%)报告了后来归因于多发性硬化症的症状误诊,这与较长的诊断延迟相关(p结论:诊断延迟普遍存在,并与多发性硬化症最初症状的频繁误诊和后来归因于多发性硬化症的早期未评估症状有关,需要对多发性硬化症患者的诊断历程进行追踪研究,以了解和预防诊断延迟的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信