Examining the role of the photopigment melanopsin in the striatal dopamine response to light.

IF 3.1 4区 医学 Q2 NEUROSCIENCES
Frontiers in Systems Neuroscience Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI:10.3389/fnsys.2025.1568878
L Sofia Gonzalez, Austen A Fisher, Kassidy E Grover, J Elliott Robinson
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引用次数: 0

Abstract

The mesolimbic dopamine system is a set of subcortical brain circuits that plays a key role in reward processing, reinforcement, associative learning, and behavioral responses to salient environmental events. In our previous studies of the dopaminergic response to salient visual stimuli, we observed that dopamine release in the lateral nucleus accumbens (LNAc) of mice encoded information about the rate and magnitude of rapid environmental luminance changes from darkness. Light-evoked dopamine responses were rate-dependent, robust to the time of testing or stimulus novelty, and required phototransduction by rod and cone opsins. However, it is unknown if these dopaminergic responses also involve non-visual opsins, such as melanopsin, the primary photopigment expressed by intrinsically photosensitive retinal ganglion cells (ipRGCs). In the current study, we evaluated the role of melanopsin in the dopaminergic response to light in the LNAc using the genetically encoded dopamine sensor dLight1 and fiber photometry. By measuring light-evoked dopamine responses across a broad irradiance and wavelength range in constitutive melanopsin (Opn4) knockout mice, we were able to provide new insights into the ability of non-visual opsins to regulate the mesolimbic dopamine response to visual stimuli.

研究光色素黑视素在纹状体多巴胺对光的反应中的作用。
中边缘多巴胺系统是一组皮层下脑回路,在奖励处理、强化、联想学习和对显著环境事件的行为反应中起着关键作用。在我们之前对显著视觉刺激多巴胺能反应的研究中,我们观察到小鼠侧伏隔核(LNAc)释放的多巴胺编码了环境亮度从黑暗快速变化的速度和幅度的信息。光诱发的多巴胺反应是速率依赖的,对测试时间或刺激新颖性具有鲁棒性,并且需要视杆蛋白和视锥蛋白的光传导。然而,尚不清楚这些多巴胺能反应是否也涉及非视觉视蛋白,如黑视素,一种由内在光敏视网膜神经节细胞(ipRGCs)表达的主要光色素。在当前的研究中,我们利用遗传编码多巴胺传感器dLight1和纤维光度法评估了黑视素在LNAc中多巴胺对光的反应中的作用。通过测量组成型黑视素(Opn4)敲除小鼠在宽辐照度和波长范围内的光诱发多巴胺反应,我们能够为非视觉视蛋白调节中脑边缘多巴胺对视觉刺激的反应能力提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Systems Neuroscience
Frontiers in Systems Neuroscience Neuroscience-Developmental Neuroscience
CiteScore
6.00
自引率
3.30%
发文量
144
审稿时长
14 weeks
期刊介绍: Frontiers in Systems Neuroscience publishes rigorously peer-reviewed research that advances our understanding of whole systems of the brain, including those involved in sensation, movement, learning and memory, attention, reward, decision-making, reasoning, executive functions, and emotions.
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