First-in-human pilot study of snapshot multispectral endoscopy for delineation of pituitary adenoma.

IF 3 3区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Journal of Biomedical Optics Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI:10.1117/1.JBO.30.5.056002
Dale J Waterhouse, Daniele Borsetto, Thomas Santarius, James R Tysome, Sarah E Bohndiek
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引用次数: 0

Abstract

Significance: The definitive treatment for pituitary adenoma is transsphenoidal surgical resection. Conventional white light imaging shows limited contrast between the adenoma and the pituitary gland, and only the tissue surface is visualized, leaving a pressing unmet need for improved intraoperative adenoma delineation to preserve pituitary function during surgery.

Aim: To evaluate the potential of multispectral imaging to enhance visualization of adenoma during transsphenoidal resection.

Approach: A multispectral camera based on a spectrally resolved detector array was coupled to a standard 4-mm rigid endoscope for in vivo imaging, such that the camera head could easily be switched with the standard of care camera head during surgery.

Results: The multispectral imaging (MSI) endoscope was deployed during transsphenoidal surgery, and usable data were obtained from 12 patients. MSI was able to distinguish between an adenoma and a healthy pituitary based on the spectral angle with the reference spectrum of blood.

Conclusions: The MSI endoscope holds the potential to differentiate adenoma tissue and healthy pituitary. With further development, MSI endoscopy could enable real-time label-free delineation of tumors during surgery, based on quantitative thresholds, which should contribute to improving the completeness of resection, while helping to preserve the pituitary gland, preventing serious life-changing complications.

快照多光谱内窥镜诊断垂体腺瘤的首次人体初步研究。
意义:垂体腺瘤的最终治疗方法是经蝶窦手术切除。传统的白光成像显示腺瘤和垂体之间的对比度有限,并且仅能看到组织表面,因此迫切需要改进术中腺瘤的描绘,以在术中保留垂体功能。目的:探讨多光谱成像在经蝶窦切除术中增强腺瘤显像的潜力。方法:将基于光谱分辨探测器阵列的多光谱相机与标准的4毫米刚性内窥镜耦合在一起进行体内成像,这样在手术过程中,相机头可以很容易地与标准护理相机头进行切换。结果:在经蝶手术中使用多光谱成像(MSI)内窥镜,获得了12例患者的可用数据。MSI能够根据与血液参考光谱的光谱角度区分腺瘤和健康垂体。结论:MSI内窥镜具有鉴别垂体腺瘤组织与健康垂体的潜力。随着进一步的发展,MSI内窥镜可以在手术中基于定量阈值实现实时无标签肿瘤描绘,这将有助于提高切除的完整性,同时有助于保存垂体,防止严重的改变生命的并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.40
自引率
5.70%
发文量
263
审稿时长
2 months
期刊介绍: The Journal of Biomedical Optics publishes peer-reviewed papers on the use of modern optical technology for improved health care and biomedical research.
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