Novel Tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine Compounds as Oxytocin Receptor Agonists for Treating Autism Spectrum Disorders.

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-04-21 eCollection Date: 2025-05-08 DOI:10.1021/acsmedchemlett.5c00190

Zhendong Song, Steven H Liang

引用次数: 0

Abstract

The present invention reveals a series of novel nonpeptidergic compounds as oxytocin receptor (OT-R) agonists. These agonists, featuring a tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine scaffold, hold the therapeutic potential for the treatment of autism spectrum disorders.

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新型四氢苯并[b]吡唑啉[3,4-e][1,4]二氮卓类化合物治疗自闭症谱系障碍的催产素受体激动剂。

本发明揭示了一系列新的非肽能化合物作为催产素受体（OT-R）激动剂。这些激动剂具有四氢苯并[b]吡唑[3,4-e][1,4]二氮卓支架，具有治疗自闭症谱系障碍的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.