The Effectiveness of Live Birth Rate of Traditional Chinese Medicine Intervention for Infertile Women Undergoing a Second Round of IVF Is Influenced by Age.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-05-01 DOI:10.21873/invivo.13963

Shu-Chiu Wang, Liang-Miin Tsai, Po-Ming Chen, Yuan-Man Hsu, Shu-Chen Wang, Chiung-Hung Chang

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引用次数: 0

Abstract

Background/aim: While in vitro fertilization (IVF) is an effective treatment for infertility, the live birth rate remains suboptimal. This study aimed to evaluate the factors influencing live birth rates in infertile women undergoing a second round of IVF combined with traditional Chinese medicine (TCM) treatment.

Patients and methods: This was a single-center, retrospective cohort study involving 45 infertile women undergoing a second round of IVF who underwent a combined treatment approach integrating TCM with IVF. Clinical factors affecting live birth rates were analyzed using Student's t test, Pearson's Chi-square test, and univariate logistic regression models.

Results: The findings revealed a clinical pregnancy rate of 51.11% and a live birth rate of 42.22%, underscoring the potential effectiveness of combining TCM with a second round of IVF for infertile women. Additionally, maternal age showed a statistically significant influence on the clinical pregnancy rate (39.32±2.93 years vs. 36.48±2.47 years, p=0.005) and live birth rate (39.68±2.85 years vs. 35.58±2.95 years, p<0.001).

Conclusion: Integrating traditional Chinese medicine into IVF protocols notably enhances maternal success rates. For women over 38, age-specific strategies such as fertility preservation, optimized ovarian stimulation, advanced embryo selection, and oocyte donation are key to addressing age-related challenges.

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中药干预对第二次体外受精不孕妇女活产率的影响

背景/目的：虽然体外受精（IVF）是治疗不孕症的有效方法，但活产率仍然不理想。本研究旨在评估影响第二轮体外受精结合中医药治疗的不孕妇女活产率的因素。患者和方法：这是一项单中心、回顾性队列研究，涉及45名接受第二轮体外受精的不孕妇女，她们接受了中医与体外受精的联合治疗方法。采用Student’st检验、Pearson’s卡方检验和单变量logistic回归模型分析影响活产率的临床因素。结果：临床妊娠率为51.11%，活产率为42.22%，提示中医药联合第二轮体外受精治疗不孕症的潜在疗效。此外，产妇年龄对临床妊娠率（39.32±2.93年vs 36.48±2.47年，p=0.005）和活产率（39.68±2.85年vs 35.58±2.95年）有统计学意义。结论：中药结合体外受精方案可显著提高产妇成功率。对于38岁以上的女性，针对年龄的策略，如保留生育能力、优化卵巢刺激、先进的胚胎选择和卵母细胞捐赠，是解决年龄相关挑战的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.