Narek Sargsyan, Iihan Ali, Christopher Namgoong, Bibek Das, Matyas Fehervari, Michael G Fadel
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引用次数: 0
Abstract
We aimed to investigate the effect of primary Roux-en-Y gastric bypass (RYGB) on gastro-oesophageal reflux disease (GORD) in patients with obesity. A systematic review was performed using MEDLINE, Embase, Emcare, and CINAHL databases for studies that reported on GORD outcomes following RYGB for obesity (January 2000-November 2023). Fourteen studies with 28,027 patients underwent RYGB, with pooled analysis demonstrating a 47% (95% CI 34.0-59.0; p ≤ 0.005) improvement in GORD symptoms and 4.5% (95% CI 1.7-7.2; p ≤ 0.005) with worsening/new onset GORD. Postoperative DeMeester score improved by 16.49 points (95% CI 0.2-32.7; p ≤ 0.005) and 79.4% (95% CI 68.7-90.1; p = 0.01) completely discontinued proton-pump inhibitor therapy during the follow-up period. RYGB surgery may potentially improve GORD symptoms in patients with obesity, with an overall low incidence of de novo GORD.
我们旨在探讨原发性Roux-en-Y胃旁路术（RYGB）对肥胖患者胃食管反流病（GORD）的影响。使用MEDLINE、Embase、Emcare和CINAHL数据库对报告RYGB治疗肥胖症后GORD结果的研究（2000年1月至2023年11月）进行系统评价。14项研究，28,027例患者接受RYGB，合并分析显示47% (95% CI 34.0-59.0；p≤0.005)，GORD症状改善4.5% (95% CI 1.7-7.2；p≤0.005)，加重/新发GORD。术后DeMeester评分提高16.49分(95% CI 0.2 ~ 32.7；p≤0.005)和79.4% (95% CI 68.7-90.1；P = 0.01)在随访期间完全停止质子泵抑制剂治疗。RYGB手术可能潜在地改善肥胖患者的GORD症状，总体上新发GORD的发生率较低。
期刊介绍：
Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions.
Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.
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