New ecdysteroids with anticomplementary activity from roots of Leuzea uniflora (L.) holub.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-05-10 DOI:10.1080/14786419.2025.2502855

Wen-Qing Du, Can Liu, Ruo-Mei Li, Ning-Ning Shi, Yan-Nan Ji, Jin-Long Qi, Yu-Cheng Gu, Chun-Hui Liang, Man-Li Zhang

引用次数: 0

Abstract

Phytochemical investigation on roots extract of Leuzea uniflora (L.) Holub led to the isolation of two novel ecdysteroids, 11α-hydroxy-25R-inokosterone (1) and 11α-hydroxy-24R, 25 R-amarasterone A (2), along with 20 known constituents. The structures of novel compounds were confirmed by NMR and ECD spectroscopy. Compounds 2 and 9 exhibited anticomplementary activity with classical pathway, their CH₅₀ values were 138.4 ± 0.07 µg·mL^-1 and 158.3 ± 0.09 µg·mL^-1, respectively.

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独花真黄根抗补体活性的新表皮甾体。

uniflora （L.）根提取物的植物化学研究Holub分离出两种新的体外甾体，11α-羟基- 25r -肌酮(1)和11α-羟基- 24r， 25 r -阿马酮A(2)，以及20种已知成分。新化合物的结构经核磁共振和ECD谱确证。化合物2和9对经典途径具有抗互补活性，CH50值分别为138.4±0.07µg·mL-1和158.3±0.09µg·mL-1。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.