The expression of circSATB2, PEAK1 in non-small cell lung cancer tissue and their relationships with clinical pathological characteristics, as well as postoperative recurrence and metastasis.

IF 1.3 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

General physiology and biophysics Pub Date : 2025-05-01 DOI:10.4149/gpb_2025005

Hui Li, Jiayun Shan, Longjian Huang

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引用次数: 0

Abstract

We studied the circSATB2 and PEAK1 expression in NSCLC tissues and their associations with clinicopathological features, recurrence, and metastasis. Tumor and adjacent tissues from 98 NSCLC patients (2019-2020) were analyzed using qPCR (circSATB2) and immunohistochemistry (PEAK1). Pearson correlation assessed circSATB2-PEAK1 mRNA relationships. Survival analysis compared high/low expression groups. Cox regression identified risk factors for recurrence/metastasis. circSATB2 and PEAK1 mRNA were upregulated in NSCLC tissues, correlating with lymph node metastasis and advanced TNM stage (IIIa). circSATB2 positively correlated with PEAK1 mRNA. High expression of both predicted poorer survival (Kaplan-Meier). Multivariate analysis identified high circSATB2, high PEAK1, lymph node metastasis, and stage IIIA as independent risk factors for postoperative recurrence/metastasis. In conclusion, elevated circSATB2 and PEAK1 in NSCLC are linked to aggressive clinicopathological features and poor prognosis, serving as biomarkers for recurrence/metastasis risk.

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circSATB2、PEAK1在非小细胞肺癌组织中的表达及其与临床病理特征及术后复发转移的关系

我们研究了circSATB2和PEAK1在NSCLC组织中的表达及其与临床病理特征、复发和转移的关系。采用qPCR （circSATB2）和免疫组织化学（PEAK1）对2019-2020年98例NSCLC患者的肿瘤和邻近组织进行分析。Pearson相关性评估了circSATB2-PEAK1 mRNA的关系。生存率分析比较高/低表达组。Cox回归确定了复发/转移的危险因素。circSATB2和PEAK1 mRNA在NSCLC组织中表达上调，与淋巴结转移和TNM晚期（IIIa）相关。circSATB2与PEAK1 mRNA呈正相关。两者的高表达预示着较差的生存（Kaplan-Meier）。多因素分析发现高circSATB2、高PEAK1、淋巴结转移和IIIA期是术后复发/转移的独立危险因素。综上所述，circSATB2和PEAK1在NSCLC中的升高与侵袭性临床病理特征和不良预后有关，可作为复发/转移风险的生物标志物。

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来源期刊

General physiology and biophysics 生物-生化与分子生物学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： General Physiology and Biophysics is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level and is published quarterly by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences.