Welding Fumes Exposure and the Risk of Head and Neck and Gastrointestinal Cancer: A Systematic Review and Meta-Analysis.

IF 2.4 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Medicina Del Lavoro Pub Date : 2025-04-17 DOI:10.23749/mdl.v116i2.16092

Andrei Cosmin Siea, Giulia Collatuzzo, Maha Hamdani, Paolo Boffetta

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引用次数: 0

Abstract

Background: The association between welding fumes and cancers other than lung cancer remains undefined. We conducted a systematic review and meta-analysis on occupational exposure to welding fumes and the risk of head and neck cancer (HN, comprising oral, pharynx, and larynx) and gastrointestinal cancer (GI, comprising esophagus, stomach, colorectal, liver, and pancreas).

Methods: A systematic search was performed in PubMed, Scopus, and Embase using PRISMA guidelines. Cohort studies on occupational exposure to welding fumes were identified. Study quality was assessed through the CASP score. Data were analyzed in random-effects models to calculate the relative risks (RR) and 95% confidence intervals (CI) of HN and GI cancer overall and stratified by cancer site.

Results: Seven independent studies with data on oral, pharynx, larynx, esophagus, stomach, colorectal, liver, or pancreas cancer were identified. We observed the following associations: HN RR=1.10 (95% CI 1.00-1.22); GI RR= 1.03 (95% CI 0.97-1.10); oral and pharynx RR=1.06 (95%, CI 0.93-1.20, eleven risk estimates); larynx RR=1.17 (95%, CI 1.01-1.37, nine risk estimates); esophagus RR=0.98 (95%, CI 0.83-1.15, three risk estimates); stomach RR= 1.10 (95%, CI 1.02-1.19, five risk estimates); colorectal RR=0.99 (95%, CI 0.85-1.15, seven risk estimates); liver RR=1.23 (95%, CI 0.79-1.90, five risk estimates); and pancreas cancer RR=1.05 (95%, CI 0.94-1.16, three risk estimates).

Conclusions: We observed an association between occupational exposure to welding fumes and larynx and stomach cancer. No association was found for other HN or GI cancers. Our study stresses the need to investigate the risk of cancers other than lung following occupational exposure to welding fumes.

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焊接烟雾暴露与头颈部和胃肠道癌症的风险：一项系统综述和荟萃分析。

背景：除肺癌外，焊接烟雾与癌症之间的关系尚不清楚。我们对职业暴露于焊接烟雾与头颈癌（HN，包括口腔癌、咽喉癌）和胃肠道癌（GI，包括食道癌、胃癌、结肠直肠癌、肝癌和胰腺癌）的风险进行了系统回顾和荟萃分析。方法：采用PRISMA指南在PubMed、Scopus和Embase中进行系统检索。确定了职业性接触焊接烟雾的队列研究。通过CASP评分评估研究质量。采用随机效应模型对数据进行分析，计算HN和GI癌症的总体相对危险度（RR）和95%置信区间（CI），并按癌症部位分层。结果：7项独立研究的数据涉及口腔癌、咽喉癌、食道癌、胃癌、结直肠癌、肝癌或胰腺癌。我们观察到以下相关性：HN RR=1.10 (95% CI 1.00-1.22)；Gi rr = 1.03 (95% ci 0.97-1.10)；口腔和咽部RR=1.06 （95%, CI 0.93-1.20, 11个风险估计）；喉部RR=1.17 （95%, CI 1.01-1.37, 9个风险估计）；食道RR=0.98 （95%, CI 0.83-1.15, 3个风险估计）；胃RR= 1.10 （95%, CI 1.02-1.19, 5个风险估计）；结直肠RR=0.99 （95%, CI 0.85-1.15, 7个风险估计）；肝脏RR=1.23 （95%, CI 0.79-1.90, 5个风险估计）；胰腺癌RR=1.05 （95%, CI 0.94-1.16，三个风险估计）。结论：我们观察到职业接触焊接烟雾与喉癌和胃癌之间的联系。与其他HN或GI癌症没有关联。我们的研究强调有必要调查职业接触焊接烟雾后患肺癌以外的癌症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Del Lavoro 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.70

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： La Medicina del Lavoro is a bimonthly magazine founded in 1901 by L. Devoto, and then directed by L. Prieti, E. Vigliani, V. Foà, P.A. Bertazzi (Milan). Now directed by A. Mutti (Parma), the magazine is the official Journal of the Italian Society of Occupational Medicine (SIML), aimed at training and updating all professionals involved in prevention and cure of occupational diseases.