Cortical Gradients Support Mental Time Travel into the Past and Future: Evidence from Activation Likelihood Estimation Meta-analysis.

Abstract

A longstanding issue concerns the extent to which episodic autobiographical memory (EAM) and episodic future thinking (EFT) are the expression of the same cognitive ability and may be dissociated at the neural level. Here, we provided an updated picture of overlaps and dissociations between brain networks supporting EAM and EFT, using Activation Likelihood Estimation. Moreover, we tested the hypothesis that spatial gradients characterize the transition between activations associated with the two domains, in line with accounts positing a transition in the relative predominance of their features and process components. We showed the involvement of a core network across EAM and EFT, including midline structures, the bilateral hippocampus/parahippocampus, angular gyrus and anterior middle temporal gyrus (aMTG) and the left superior frontal gyrus (SFG). Contrast analyses highlighted a cluster in the right aMTG significantly more activated during EFT compared with EAM. Finally, gradiental transitions were found in the ventromedial prefrontal cortex, left SFG, and bilateral aMTG. Results show that differences between EAM and EFT may arise at least partially through the organization of specific regions of common activation along functional gradients, and help to advocate between different theoretical accounts.