To be or not to be: review on multidisciplinary management of agenesis of corpus callosum.

Abstract

The corpus callosum (CC) is the most significant of the three cerebral commissures that join the human left and right hemispheres. Numerous vascular, chemical, genetic, and metabolic disturbances can impede the growth of the CC. Complete agenesis of the CC is the most prevalent abnormality. As a result of improvements in our knowledge and advancements in ultrasonography technology, an increasing number of congenital CC abnormalities have been identified. Prenatal magnetic resonance imaging is crucial to identify related central nervous system abnormalities. Counseling about the postnatal result is still difficult. This study sought to characterize the long-term consequences for children with isolated anomalies of CC detected during pregnancy, trying to provide the correct multidisciplinary approach to the pregnant woman also in terms of medical legal and ethical issues.