Increases in cardiac vagal modulation following muscle mechanoreflex activation via passive calf stretch: Impact of interindividual differences.

IF 2.8 4区 医学 Q2 PHYSIOLOGY
Georgia C S Lehnen, Marcela S Araujo, Igor S Rocha, Jeann L Sabino-Carvalho, Rosa V D Guerrero, Gabriel S Trajano, Lauro C Vianna
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Abstract

Muscle mechanoreflex is crucial to cardiac vagal modulation during exercise and can be activated during passive calf stretch. Herein, we aimed to determine whether cardiac vagal modulation following a single session of passive stretch is linked to interindividual cardiac vagal responses at the onset of passive calf muscle stretching in healthy young adults. Twenty-four volunteers (10 women) completed the experimental conditions in a randomised order over different days: a time-control condition and five sets of 1 min of unilateral passive stretching of the calf, with 15 s of rest between each stretching trial. Heart rate and systolic and diastolic blood pressure were continuously measured on a beat-to-beat basis before, immediately following, and at 15 and 30 min after the passive stretching intervention. Interindividual variations in cardiac vagal inhibition during the passive stretching session were identified, classifying volunteers into responder (n = 16) and non-responder (n = 8) groups. The onset of passive muscle stretching elicited an immediate reduction in cardiac vagal modulation (P = 0.026) and an increase in heart rate (P = 0.009) for the responders only. Cardiac vagal modulation significantly increased following 30 min of passive stretching (P = 0.010 vs. rest) for the responders only. During time control, all cardiac vagal variables were unchanged for both groups. In summary, our findings demonstrate that a single session of passive calf muscle stretching can enhance cardiac vagal modulation, but this effect is dependent on interindividual responses at the onset of stretching. These results highlight the role of muscle mechanoreflex activation in cardiac autonomic regulation and suggest that passive stretching may have potential cardiovascular benefits, particularly for individuals who exhibit a mechanoreflex-mediated response.

通过被动小腿拉伸激活肌肉机械反射后心脏迷走神经调节的增加:个体间差异的影响。
在运动过程中,肌肉机械反射对心脏迷走神经调节至关重要,可以在被动的小腿拉伸中激活。在此,我们的目的是确定在健康年轻人被动小腿肌肉拉伸开始时,单次被动拉伸后的心脏迷走神经调节是否与个体间心脏迷走神经反应有关。24名志愿者(10名女性)在不同的日子里按随机顺序完成了实验条件:时间控制条件和五组1分钟的单侧被动小腿拉伸,每次拉伸试验之间休息15秒。在被动拉伸干预之前、之后、15分钟和30分钟,连续测量心率、收缩压和舒张压。在被动拉伸过程中,确定了心脏迷走神经抑制的个体差异,并将志愿者分为有反应组(n = 16)和无反应组(n = 8)。被动肌肉拉伸的开始只引起反应者心脏迷走神经调节的立即减少(P = 0.026)和心率的增加(P = 0.009)。被动拉伸30分钟后,心脏迷走神经调节显著增加(P = 0.010 vs.休息)。在时间控制期间,两组的所有心脏迷走神经变量不变。总之,我们的研究结果表明,单次被动小腿肌肉拉伸可以增强心脏迷走神经调节,但这种效果取决于拉伸开始时的个体间反应。这些结果强调了肌肉机械反射激活在心脏自主调节中的作用,并表明被动拉伸可能具有潜在的心血管益处,特别是对于表现出机械反射介导反应的个体。
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来源期刊
Experimental Physiology
Experimental Physiology 医学-生理学
CiteScore
5.10
自引率
3.70%
发文量
262
审稿时长
1 months
期刊介绍: Experimental Physiology publishes research papers that report novel insights into homeostatic and adaptive responses in health, as well as those that further our understanding of pathophysiological mechanisms in disease. We encourage papers that embrace the journal’s orientation of translation and integration, including studies of the adaptive responses to exercise, acute and chronic environmental stressors, growth and aging, and diseases where integrative homeostatic mechanisms play a key role in the response to and evolution of the disease process. Examples of such diseases include hypertension, heart failure, hypoxic lung disease, endocrine and neurological disorders. We are also keen to publish research that has a translational aspect or clinical application. Comparative physiology work that can be applied to aid the understanding human physiology is also encouraged. Manuscripts that report the use of bioinformatic, genomic, molecular, proteomic and cellular techniques to provide novel insights into integrative physiological and pathophysiological mechanisms are welcomed.
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