Treatment Strategies and Effectiveness in Lymphatic Malformations: A 10-Year Retrospective Study.

Lymphology Pub Date : 2025-01-01
M Shiraishi, M Narushima, C H Banda, Y Moriwaki, K Kojima, K Yamagata, C Kondo, K Mitsui, K Hashimoto, K Danno, K Hosomi, R Ishiura, M Kurita, I Koshima
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Abstract

Recurrence is a major challenge in treatment of lymphatic malformations (LMs) world-wide. The objectives of the current study were to investigate risk factors associated with LM recurrence and to compare effectiveness of surgical and endovascular treatments. A multi-center 10-year retrospective chart review was conducted on all consecutive patients treated for LMs from 2009 to 2019. Data collected included post-treatment size, symptoms, and recurrence. Stepwise multiple regression analysis was used to identify risk factors and to compare treatment modalities. A total of 13 patients with 20 treatment cases were included. No significant difference was observed in size reduction and symptom alleviation between the treatment groups. Resection showed the highest recurrence rate of 36.4% (p=0.04) and lymphaticovenular anastomosis (LVA) presented excel-lent results in post-treatment size, symptoms, and recurrence despite lack of statistical significance. Microcystic type of LMs was identified as an independent risk factor for recurrence. Both surgery and sclerotherapy are effective in improving size and symptoms of LMs. This data will help physicians and patients choose the optimal treatment and potentially predict progression.

淋巴畸形的治疗策略和疗效:一项10年回顾性研究。
复发是淋巴畸形(LMs)治疗的主要挑战。本研究的目的是探讨与LM复发相关的危险因素,并比较手术和血管内治疗的有效性。对2009年至2019年连续治疗的所有LMs患者进行了多中心10年回顾性图表回顾。收集的数据包括治疗后的大小、症状和复发。采用逐步多元回归分析确定危险因素并比较治疗方式。共纳入13例患者,20例治疗病例。两组间在体积缩小和症状缓解方面无显著差异。术后复发率最高,为36.4% (p=0.04),淋巴小囊吻合(LVA)虽无统计学意义,但术后大小、症状、复发率均较好。微囊型LMs被确定为复发的独立危险因素。手术和硬化疗法都能有效地改善LMs的大小和症状。这些数据将帮助医生和患者选择最佳治疗方法,并有可能预测病情进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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