Atypical Applications of Neuromodulation for Non-Painful Conditions.

IF 3.2 2区 医学 Q2 CLINICAL NEUROLOGY
Ashlyn Brown, Loc Lam, Billy Huh, Ryan S D'Souza, Saba Javed
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Abstract

Purpose of review: This narrative review explores the expanding applications of neuromodulation beyond pain management, focusing on its use in treating non-painful conditions such as heart failure, renal failure, spinal cord injuries, overactive bladder syndrome, and cognitive impairment in neurodegenerative diseases.

Recent findings: Neuromodulation techniques, including dorsal root ganglion stimulation, sacral neurostimulation, and deep brain stimulation, have shown promising results in various non-painful medical conditions: Heart and Renal Failure: Dorsal root ganglion stimulation induces diuresis in diuretic-resistant patients, offering a novel approach to managing fluid overload. Spinal Cord Injuries: Epidural spinal cord stimulation and brain-spine interfaces have demonstrated the potential to restore motor function, enhancing mobility and quality of life for paralyzed individuals. Overactive Bladder Syndrome: Sacral neurostimulation and tibial nerve stimulation have proven effective in improving urinary continence and reducing symptoms in patients unresponsive to conventional treatments. Cognitive Impairment in Neurodegenerative Diseases: Techniques such as deep brain stimulation and transcranial magnetic stimulation are being investigated for their ability to enhance cognitive and motor functions in conditions like Parkinson's and Alzheimer's disease. The review highlights the transformative potential of neuromodulation in non-painful conditions, demonstrating its ability to address complex medical issues beyond its traditional scope. Continued research and optimization of these techniques may lead to broader therapeutic applications and improved patient outcomes.

神经调节在非疼痛性疾病中的非典型应用。
综述目的:这篇叙述性综述探讨了神经调节在疼痛管理之外的扩展应用,重点是它在治疗非疼痛性疾病中的应用,如心力衰竭、肾衰竭、脊髓损伤、膀胱过度活动综合征和神经退行性疾病中的认知障碍。最近的发现:神经调节技术,包括刺激背根神经节、骶神经刺激和深部脑刺激,在各种非痛苦的医疗条件下显示出有希望的结果:心脏和肾衰竭:刺激背根神经节可诱导利尿抵抗患者的利尿,提供了一种管理液体过载的新方法。脊髓损伤:硬膜外脊髓刺激和脑-脊柱接口已经证明了恢复运动功能,提高瘫痪患者的活动能力和生活质量的潜力。膀胱过度活动综合征:骶神经刺激和胫神经刺激已被证明对改善尿失禁和减轻对常规治疗无反应的患者的症状有效。神经退行性疾病中的认知障碍:诸如脑深部刺激和经颅磁刺激等技术正在被研究,因为它们能够增强帕金森病和阿尔茨海默病等疾病的认知和运动功能。这篇综述强调了神经调节在非疼痛条件下的变革性潜力,证明了它在解决传统范围之外的复杂医学问题方面的能力。这些技术的持续研究和优化可能会导致更广泛的治疗应用和改善患者的预后。
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来源期刊
Current Pain and Headache Reports
Current Pain and Headache Reports CLINICAL NEUROLOGY-
CiteScore
6.10
自引率
2.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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