Mucosal Wetness, Hyposalivation, and Local Defense in Periodontal Inflammation.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-08-01 Epub Date: 2025-04-22 DOI:10.1111/odi.15339

Buket Acar, Mehmet Özcan, Havanur Toz, Nagihan Koç, Barış Sarp Sevimli, Berke Berberoglu, Ayşe Buruş, Erdem Karabulut, Yasemin Bayazıt, Nermin Tarhan

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引用次数: 0

Abstract

Objective: To evaluate the potential relationship between local salivary coating of mucosal surfaces, clinical periodontal status, hyposalivation, and local inflammatory response with a specific reference for MUC4 and TNF-α levels.

Materials and methods: Based on their salivary flow rates, 24 hyposalivators and 26 normosalivators were recruited. Mucosal wetness (MW) and mucosal surface pH values were determined. Clinical periodontal parameters were recorded and gingival crevicular fluid (GCF) samples were obtained. Mucin 4 (MUC4) and TNF-α levels in local and whole salivary and GCF samples were determined with ELISA kits.

Results: GI and BoP were significantly higher in the hyposalivation group, while MW and mucosal pH values were significantly lower in hyposalivators, except for the labial surface. MUC4 and TNF-α levels showed significant differences among the groups. In the anterior region, GCF TNF-α concentration was high in hyposalivation patients; in the molar region, GCF MUC4 was significantly higher in normosalivators.

Conclusions: Based on the differences which MW presented at local sites, MW may be utilized as a possible practical tool to reveal the local salivary characteristics in various clinical periodontal conditions based on the presence/extent of local inflammatory response, which may be important when the site-specific nature of periodontal diseases is concerned.

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牙周炎症中的粘膜湿润、唾液分泌不足和局部防御。

目的：以MUC4和TNF-α水平为参考，探讨粘膜表面局部唾液包被、临床牙周状况、唾液分泌不足和局部炎症反应之间的潜在关系。材料与方法：根据大鼠唾液流速，选取唾液分泌减退者24例，正常唾液分泌者26例。测定粘膜湿度（MW）和粘膜表面pH值。记录临床牙周参数，采集龈沟液（GCF）样本。采用ELISA试剂盒检测局部、全口唾液和GCF样品中Mucin 4 （MUC4）和TNF-α水平。结果：除唇面外，低渗组的GI和BoP均显著升高，低渗组的MW和粘膜pH值均显著降低。各组间MUC4、TNF-α水平差异有统计学意义。在前区，低通气患者的GCF TNF-α浓度较高；在磨牙区，正常唾液分泌者GCF MUC4显著升高。结论：基于局部部位的差异，基于局部炎症反应的存在/程度，MW可以作为一种可能的实用工具来揭示各种临床牙周病的局部唾液特征，这在牙周病的部位特异性方面可能是重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.