Obesity, Nutritional Intake, and Age-Related Macular Degeneration: A Cross-Sectional Study Using Nationwide Survey Data from Korea.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2025-05-05 DOI:10.1080/09286586.2025.2500023

Mingui Kong, Mi Yeon Lee, Wonjin Yang, Jeong Hun Bae, Joon Mo Kim

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引用次数: 0

Abstract

Purpose: Dietary intake of nutrients seems to play a role in the prevention of age-related macular degeneration (AMD). It may be worthwhile to identify certain nutrients that are highly related to AMD when consumed in small amounts. This study aims to evaluate the association between nutritional intake and risk of AMD.Methods: A population-based cross-sectional study analyzed data from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2010 and 2011, involving 6,471 participants aged 40 years or older. The presence and severity of AMD were graded using fundus photography. Multivariable regression analysis was employed to assess the association between dietary intake and AMD risk.Results: The prevalence of AMD among 6,471 participants was 8.9% (576 cases), comprising 8.2% (531) with early AMD and 0.7% (45) with late AMD. Multivariable-adjusted analyses revealed that, among obese individuals (body mass index ≥25), men with AMD had significantly lower intakes of fiber, ash, calcium, potassium, thiamin, and vitamin C compared to those without AMD (all p < 0.05). In obese women, AMD showed a significant association with lower intakes of protein, vitamin A, and carotene (all p < 0.05).Conclusions: An insufficient intake of certain nutrients was associated with an increased likelihood of AMD in obese individuals. Larger prospective cohort studies are needed to investigate the relationship between specific nutrients and the risk of AMD.

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肥胖、营养摄入和年龄相关性黄斑变性：一项使用韩国全国调查数据的横断面研究。

目的：膳食营养摄入似乎在预防老年性黄斑变性（AMD）中发挥作用。当少量摄入时，确定与AMD高度相关的某些营养素可能是值得的。本研究旨在评估营养摄入与AMD风险之间的关系。方法：一项基于人群的横断面研究分析了2010年至2011年韩国国家健康与营养调查（KNHANES）的数据，涉及6471名年龄在40岁或以上的参与者。采用眼底摄影对AMD的存在和严重程度进行分级。采用多变量回归分析评估饮食摄入与AMD风险之间的关系。结果：6471名参与者中AMD患病率为8.9%（576例），其中早期AMD患病率为8.2%（531例），晚期AMD患病率为0.7%（45例）。多变量调整分析显示，在肥胖个体（体重指数≥25）中，与没有AMD的人相比，患有AMD的男性纤维、灰分、钙、钾、硫胺素和维生素C的摄入量显著降低（所有p）。结论：某些营养素摄入不足与肥胖个体AMD的可能性增加有关。需要更大规模的前瞻性队列研究来调查特定营养素与AMD风险之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.